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. 2024 Aug;60(4):393-401.
doi: 10.1007/s11262-024-02076-5. Epub 2024 May 29.

The full genome characterization of avian encephalomyelitis virus, Iran: a vertical transmission case

Arash Ghalyanchilangeroudi  1 , Seyed Ahmad Madani  2 , Hamideh Najafi  1 , Zahra Ziafati Kafi  1 , Naser Sadri  1 , Soroush Sarmadi  1 , Omid Eghbali  1 , Fahimeh Jamiri  1 , Alireza Bakhshi  1 , Hossein Hosseini  3
Affiliations

The full genome characterization of avian encephalomyelitis virus, Iran: a vertical transmission case

Arash Ghalyanchilangeroudi et al. Virus Genes. 2024 Aug.

Abstract

Avian encephalomyelitis (AE) is an important infectious poultry disease worldwide that is caused by avian encephalomyelitis virus (AEV). The causative virus can be transmitted both horizontally and vertically. In the present study, an AEV suspected outbreak with typical neurological signs occurred in broilers. Histopathological examination, RT-PCR assay and full genome sequencing were applied to confirm the presence of AEV. Phylogenetic analysis of the full genome sequence showed that the detected AEV strain at 7055 nucleotide length is classified in cluster I and is closely related to vaccinal USA and China originated isolates. Although, the outbreaks of AE in progeny of vaccinated breeders have been reported previously, the source of infection was unknown. Based on the results obtained in this study, the outbreaks are vaccine-originated. This study provides the first whole genome analysis of AEV from Iran and reveals that the AEV possesses a hepatitis C virus-like internal ribosome entry site.

Keywords: Avian encephalomyelitis; Complete genome; Iran; Phylogenetic analysis; Vaccine.

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