Progress in therapeutic targets on podocyte for Alport syndrome

Qimin Zheng^{1

2}, Xiangchen Gu^{1

2}, John Cijiang He³, Jingyuan Xie^{1

2}

Affiliations

¹ Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
² Institute of Nephrology, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
³ Department of Medicine, Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, USA.

Qimin Zheng et al. J Transl Int Med. 2024.

. 2024 May 21;12(2):129-133.

doi: 10.2478/jtim-2024-0005. eCollection 2024 Apr.

Qimin Zheng^{1

2}, Xiangchen Gu^{1

2}, John Cijiang He³, Jingyuan Xie^{1

2}

¹ Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
² Institute of Nephrology, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
³ Department of Medicine, Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, USA.

No abstract available

Keywords: Alport syndrome; podocyte; therapeutic targets.

Conflict of interest statement

Conflict of Interest None declared.

1. Gibson J, Fieldhouse R, Chan MMY, Sadeghi-Alavijeh O, Burnett L, Izzi V. Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in a Population Sequencing Database and Their Implications for Alport Syndrome. J Am Soc Nephrol. 2021;32:2273. et al. –. - PMC - PubMed
1. Kashtan CE, Ding J, Garosi G, Heidet L, Massella L, Nakanishi K. Alport syndrome: a unified classification of genetic disorders of collagen IV α345: a position paper of the Alport Syndrome Classification Working Group. Kidney Int. 2018;93:1045. et al. –. - PubMed
1. Li Y, Groopman EE, D’Agati V, Prakash S, Zhang J, Mizerska-Wasiak M. Type IV Collagen Mutations in Familial IgA Nephropathy. Kidney Int Rep. 2020;5:1075. et al. –. - PMC - PubMed
1. Xie J, Wu X, Ren H, Wang W, Wang Z, Pan X. COL4A3 mutations cause focal segmental glomerulosclerosis. J Mol Cell Biol. 2014;6:498. et al. –. - PubMed
1. Wang Y, Zhang J, Zhao Y, Wang S, Zhang J, Han Q. COL4A3 Gene Variants and Diabetic Kidney Disease in MODY. Clin J Am Soc Nephrol. 2018;13:1162. et al. –. - PMC - PubMed