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. 2024 May 14:11:1375545.
doi: 10.3389/fnut.2024.1375545. eCollection 2024.

Association between oxidative balance score and hearing loss: a cross-sectional study from the NHANES database

Zhongming Zhou  1 , Yanyan Han  1
Affiliations

Association between oxidative balance score and hearing loss: a cross-sectional study from the NHANES database

Zhongming Zhou et al. Front Nutr. .

Abstract

Aim: The oxidative balance score (OBS), a composite score of dietary nutrients and lifestyles, reflects an individual's oxidative and antioxidant status. Evidence showed that oxidative stress levels were related to hearing loss. The relationship between OBS and hearing loss remains unclear. This study was to explore the association between OBS and hearing loss in adults.

Methods: In this cross-sectional study, data of participants aged 20-69 years who received hearing tests were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2011-2012, 2015-2016). Hearing loss was defined as hearing threshold >25 dB in either ear. The OBS was composed of 16 dietary nutrients and 4 lifestyles. The covariates were screened using the backward stepwise regression analysis. The association of OBS and hearing loss was assessed with odds ratios (ORs) and 95% confidence intervals (CIs). Subgroups of age, gender, occupational noise exposure, recreational noise exposure, firearm noise exposure, and veteran status were further evaluated the associations. The importance ranking of OBS components was analyzed by the weighted random forest model.

Results: Of the total 3,557 adults, 338 (9.5%) suffered from hearing loss. High OBS levels were associated with lower odds of hearing loss (OR = 0.58, 95%CI: 0.41-0.82), after adjusting age, gender, race, hypertension, tinnitus, recreational noise exposure, and occupational noise exposure. Similar results were discovered in individuals aged50-59 years old (OR = 0.47, 95%CI: 0.24-0.93), aged 60-69 years old (OR = 0.31, 95%CI: 0.16-0.61), with female (OR = 0.44, 95%CI: 0.20-0.96), without occupational noise exposure (OR = 0.31, 95%CI: 0.16-0.62), recreational noise exposure (OR = 0.48, 95%CI: 0.30-0.76), firearm noise exposure (OR = 0.38, 95%CI: 0.19-0.77), and veteran status (OR = 0.57, 95%CI: 0.39-0.82). In OBS components, vitamin B12, total fat and physical activity were important for hearing loss.

Conclusion: Elevated OBS may be associated with hearing health in adults. Appropriate vitamin B12 supplementation, reduction of total fat intake, and increased physical activity may be beneficial to the prevention of hearing loss.

Keywords: NHANES database; association; cross-sectional study; hearing loss; oxidative balance score.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The screening flowchart of participants aged 20–69 years old.
Figure 2
Figure 2
Associations of OBS with hearing in subgroups of age, gender, occupational noise exposure, recreational noise exposure, firearm noise exposure, and veteran status.
Figure 3
Figure 3
The importance ranking of OBS components.
See this image and copyright information in PMC

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References

    1. World Health Organization . World report on hearing. Geneva, Switzerland: World Health Organization; (2021).
    1. Hearing Loss Prevalence and Years Lived with Disability . 1990-2019: findings from the global burden of disease study 2019. Lancet. (2021) 397:996–1009. doi: 10.1016/s0140-6736(21)00516-x - DOI - PMC - PubMed
    1. Nelson DI, Nelson RY, Concha-Barrientos M, Fingerhut M. The global burden of occupational noise-induced hearing loss. Am J Ind Med. (2005) 48:446–58. doi: 10.1002/ajim.20223 - DOI - PubMed
    1. Tang D, Tran Y, Dawes P, Gopinath B. A narrative review of lifestyle risk factors and the role of oxidative stress in age-related hearing loss. Antioxidants (Basel). (2023) 12:878. doi: 10.3390/antiox12040878 - DOI - PMC - PubMed
    1. National Bureau of Statistics of the People’s Republic of China . The Main data bulletin of the second National Sampling Survey for the disabled (Number 2). Available at: http://www.gov.cn/fwxx/cjr/content_1308391.html. Accessed 5 Jan 2020.