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Case Reports
. 2024 Jan-Dec:12:23247096231204736.
doi: 10.1177/23247096231204736.

Isolated Cutaneous Chronic Lymphocytic Leukemia: A Case Report

Zahra Kmira  1 , Ben Ismail Hajer  1 , Mokni Sana  1 , Ben Sayed Nesrine  1 , Guermazi Monia  1 , Tabka Meriem  1 , Chiba Dorra  1 , Bouteraa Walid  1 , Zaier Monia  1 , Sriha Badreddine  1 , Ben Youssef Yosra  1 , Regaieg Haifa  1 , Khelif Abderrahim  1
Affiliations
Case Reports

Isolated Cutaneous Chronic Lymphocytic Leukemia: A Case Report

Zahra Kmira et al. J Investig Med High Impact Case Rep. 2024 Jan-Dec.

Abstract

Skin lesions in chronic lymphocytic leukemia (CLL) have been reported in between 4% and 20% of patients with CLL and are a rare entity compared with T-cell leukemia. They can present mainly as leukemic cutis or, frequently, as secondary lesions such like urticaria, itching, pyoderma gangrenosum, cutaneous vasculitis, Sweet's syndrome, and erythroderma. We report on an adult patient who developed a skin lesion of forearms and hands, leading to the discovery of isolated cutaneous CLL after two biopsies. Isolated CLL cutaneous location is very rare and may be diagnosed late, as in the case of our patient. A better knowledge of the course of the illness and rapid diagnosis of this CLL cutis leukemia will enhance the therapeutic efficacy of the disease.

Keywords: chronic lymphocytic leukemia; leukemic cutis; treatment.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Vegetating and ulcerated skin lesions in the left forearm and hand.
Figure 2.
Figure 2.
(A) Histopathology demonstrating dense mononuclear cell infiltrate (hematoxylin and eosin; 100×). (B) Immunohistochemical (IHC) stains strongly and diffusely positive for CD20; 200×. (C) IHC stain positive for CD5; 200×. (D) IHC stain positive for CD23; 200×.
See this image and copyright information in PMC

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