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Multicenter Study
. 2024 Aug;71(8):e31124.
doi: 10.1002/pbc.31124. Epub 2024 May 30.

Choriocarcinoma in neonates and infants: A severe but curable disease

Marie Pierre Castex  1 , Joanna Stefanowicz  2 , Laura Clement  1 , Jadwiga Węcławek-Tompol  3 , Frederic Hameury  4 , Brice Fresneau  5 , Sabine Irtan  6 , Anne Cecile Brunac  7 , Danuta Januszkiewicz-Lewandowska  8 , Brigitte Lacour  9   10 , Cécile Faure-Conter  11 , Daniel Orbach  12
Affiliations
Multicenter Study

Choriocarcinoma in neonates and infants: A severe but curable disease

Marie Pierre Castex et al. Pediatr Blood Cancer. 2024 Aug.

Abstract

Choriocarcinoma in neonates and infants (N-CC) is an extremely rare, but aggressive cancer, frequently observed with concomitant maternal disease. A retrospective, bi-national study of patients treated in France and Poland for infantile choriocarcinoma analysed eight cases of N-CC, median age of 6 weeks. All tumours were diffuse. Six patients received a platinum-based regimen, and five had delayed surgery on residual distant tumour sites. At the end of follow-up, four patients were in complete remission and four had died of the disease. In all but two cases, mothers had simultaneous metastatic choriocarcinoma. Even if the outcome remains poor, patients could be cured with multimodal therapy.

Keywords: chemotherapy; choriocarcinoma; maternofoetal transmission; neonatal tumour.

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References

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