Inhibition of growth hormone release by rumen distension in female goats

Abstract

Six rumen-fistulated, overnight-fasted, female British Saanen goats were used. In preliminary experiments on two of the goats, evidence was obtained that inflation of a balloon with water in the cranial sac of the rumen was accompanied by inhibition of GH release. In a definitive series of experiments on the other four goats (one goat on 1 day = one experiment), a total of 96 experiments were carried out, 48 of which were balloon inflations with 2.5 litres water at 37 degrees C in the cranial sac of the rumen for 40 min and 48 were control experiments on alternate days. It was found that the mean plasma GH concentration of the samples taken at the end of the 40-min inflation period was significantly (P less than 0.05) lower than the mean value of the samples taken at the start of inflation. Mean control values at the start and finish of inflation were not significantly different. There were no significant differences between mean plasma insulin concentrations at the start and finish of inflation in experimental and control groups. It is concluded that distension of the cranial rumen in the goat is a signal which can inhibit the release of GH.