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. 2024 Jul;49(7):567-568.
doi: 10.1016/j.tibs.2024.05.005. Epub 2024 May 29.

Subconductance states add complexity to Piezo1 gating model

Marie E Cronin  1 , Jörg Grandl  2
Affiliations

Subconductance states add complexity to Piezo1 gating model

Marie E Cronin et al. Trends Biochem Sci. 2024 Jul.

Abstract

Piezos are force-gated ion channels that detect and communicate membrane tension to the cell. Recent work from Ullah, Nosyreva, and colleagues characterizes partial channel openings, known as subconductance states, and develops a new gating model of Piezo1 function.

Keywords: Piezo channels; force-gated ion channels; gating model; mechanotransduction; subconductance states.

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Conflict of interest statement

Declaration of interests No competing interests are declared.

Figures

Figure 1.
Figure 1.. Piezo1 channels can occupy subconductance states.
(Left) Illustration of cell-attached patch-clamp configuration. Negative pressure inside the patch pipette activates Piezo1. (Right) Pores in the closed/inactivated, fully opened, and subconducting states. Yellow arrows indicate current amplitudes. (Bottom) Simulated current trace showing closed, fully, and partially conducting states.
See this image and copyright information in PMC

References

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