Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 15;10(1):FSO981.
doi: 10.2144/fsoa-2023-0248. eCollection 2024.

Arthritis alleviation: unveiling the potential in Abrus precatorius macerated oil

Sukanya Vijayan  1 , Thirumal Margesan  1
Affiliations

Arthritis alleviation: unveiling the potential in Abrus precatorius macerated oil

Sukanya Vijayan et al. Future Sci OA. .

Abstract

Aim: This study endeavors to explore the anti-arthritic effects of macerated oil derived from the plant's aerial parts. Methods: The macerated oil was prepared using maceration in coconut oil, and its phytochemical composition was elucidated using GC-MS. To assess its anti-arthritic activity, in-vitro studies were conducted using various assays. Results & conclusion: The macerated oil showed better antioxidant and anti-arthritic potential by in-vitro investigations. Molecular docking studies elucidated potential binding interactions between specific constituents of the oil and critical molecular targets implicated in the pathogenesis of arthritis, further substantiating its therapeutic potential. The results demonstrated that Abrus precatorius macerated oil could ameliorate arthritis severity in a dose-dependent manner.

Keywords: Abrus precatorius; anti-arthritic; antioxidant; macerated oil; molecular docking.

Plain language summary

The study explores whether the oil from the Abrus precatorius plant can help people with arthritis. Arthritis is a painful condition that causes swelling and stiffness in the joints. Researchers are curious if this plant oil can ease the pain and reduce inflammation associated with arthritis. They are conducting experiments to see if it works and is safe to use. In the research, we study the effects of this plant oil on arthritis symptoms. This oil is obtained by soaking Abrus precatorius plant parts in coconut oil. Our results could offer a new and natural way to alleviate arthritis symptoms for those who suffer from it. This would be a significant finding as it might provide a less invasive and potentially more accessible option for managing arthritis discomfort. However, it is important to remember that more research is needed to ensure the oil is both effective and safe for arthritis relief.

PubMed Disclaimer

Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Abrus precatorius plant.
Figure 2.
Figure 2.
Calibration curve of gallic acid at various concentrations.
Figure 3.
Figure 3.
Calibration curve of tannic acid at various concentrations.
Figure 4.
Figure 4.
Calibration curve of cortisone acetate at various concentrations.
Figure 5.
Figure 5.
DPPH scavenging activity.
Figure 6.
Figure 6.
ABTS scavenging activity.
Figure 7.
Figure 7.
Ferric reducing activity of macerated oil.
Figure 8.
Figure 8.
Nitric oxide scavenging activity.
Figure 9.
Figure 9.
Albumin denaturation assay.
Figure 10.
Figure 10.
Proteinase inhibition assay.
Figure 11.
Figure 11.
Chromatogram of macerated oil using gas chromatography and mass spectroscopy.
Figure 12.
Figure 12.
Bioactive compounds present in Abrus precatorius macerated oil docked with TNF -α (2AZ5).
Figure 12.
Figure 12.
Bioactive compounds present in Abrus precatorius macerated oil docked with TNF -α (2AZ5).
Figure 13.
Figure 13.
Bioactive compounds present in Abrus precatorius macerated oil docked with IL-6 (1ALU).
Figure 13.
Figure 13.
Bioactive compounds present in Abrus precatorius macerated oil docked with IL-6 (1ALU).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Jang S, Kwon E-J, Lee JJ. Rheumatoid arthritis: pathogenic roles of diverse immune cells. Int. J. Mol. Sci. 23(2), 905 (2022). - PMC - PubMed

    2. • Discusses about the background of the study and are of interest (1–27).

    1. Littlejohn EA, Monrad SU. Early diagnosis and treatment of rheumatoid arthritis. Prim. Care 45(2), 237–255 (2018). - PubMed
    1. Favalli EG, Biggioggero M, Crotti C, Becciolini A, Raimondo MG, Meroni PL. Sex and management of rheumatoid arthritis. Clin. Rev. Allergy Immunol. 56(3), 333–345 (2019). - PubMed
    1. Maranini B, Bortoluzzi A, Silvagni E, Govoni M. Focus on sex and gender: what we need to know in the management of rheumatoid arthritis. J. Pers. Med. 12(3), 499 (2022). - PMC - PubMed
    1. Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 31(1), 3–18 (2017). - PMC - PubMed

LinkOut - more resources