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Case Reports
. 2024 May 20;10(1):FSO912.
doi: 10.2144/fsoa-2023-0127. eCollection 2024.

Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report

Manel Moalla  1 , Rania Hajji  1 , Slim Charfi  2 , Mona Boudabous  1 , Hela Gdoura  1 , Leila Mnif  1 , Ali Amouri  1 , Tahya Boudawara  2 , Lassaad Chtourou  1 , Nabil Tahri  1
Affiliations
Case Reports

Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report

Manel Moalla et al. Future Sci OA. .

Abstract

Bladder metastasis of gastric adenocarcinoma is a rare phenomenon. Hereby, we report a case of a 52-year-old patient who presented with upper gastro-intestinal bleeding and ascites and was diagnosed with gastric signet-ring cell carcinoma. A CT scan revealed peritoneal infiltration and anterior parietal thickening of bladder wall. Cystoscopy showed three budding lesions of the anterior wall of the bladder. He had an endoscopic resection. Histology concluded that the bladder was infiltrated by a poorly differentiated carcinoma with independent cells consistent with a gastric origin. The patient was to be treated with palliative chemotherapy.

Keywords: adenocarcinoma; bladder metastasis; gastric cancer; signet-ring cell carcinoma.

Plain language summary

We report a case of a 52-year-old patient who presented with symptoms such as stomach bleeding and a buildup of fluid in the stomach (ascites). The doctors diagnosed the patient with gastric cancer. The doctors also noted a thickening in the wall of the bladder during a CT scan. After more investigations, they discovered that the cancer from the stomach had spread to the bladder (metastasis).

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Poorly cohesive carcinoma invading the fundic mucosa (HE × 100).
Figure 2.
Figure 2.
CT scan showing ascites, peritoneal and bladder parietal thickening. (A) Contrast enhanced CT scan demonstrating ascites and peritoneal thickening. (B) Contrast enhaced CT scan demonstrating bladder thickening.
Figure 3.
Figure 3.
Histological examination of bladder biopsies. (A) Diffuse infiltration of the bladder mucosa by poorly cohesive neoplastic cells (HE × 100). (B) important immunostaining of neoplastic cells by keratin (×200).
See this image and copyright information in PMC

References

    1. Okutur K, Eren OO, Demir G. Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature. Case Rep. Oncol. Med. 2015, 1–6 (2015). - PMC - PubMed

    2. • Exposes a literature review.

    1. Kazaz İO, Arslan A, Çolak F, Kazaz SN, Mungan S, Karagüzel E. Bladder metastasis of gastric signet-ring cell carcinoma. Urol. Case Rep. 22, 62–63 (2019). - PMC - PubMed
    1. Sato N, Kinoshita A, Imai Net al. . A Case of Advanced Gastric Cancer with Bladder Metastasis. Gan To Kagaku Ryoho. 45(9), 1361–1363 (2018). - PubMed
    1. Khoury R, Dragean, Annet L. Bladder Metastasis of Gastric Adenocarcinoma. J. Belg. Soc. Radiol. 103(1), 24 (2019). - PMC - PubMed
    1. Nouioui MA, Saadi A, Chakroun Met al. . Unusual Bladder Metastasis from a Primary Gastric Carcinoma: Two Case Reports and Review of Literature. Goel A, editor. Case Rep. Urol. 2020, 1–7 (2020). - PMC - PubMed

    2. • This is a recent literature review describing similar cases reports to this case.

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