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Review
. 2024 Apr 22;15(11):3254-3271.
doi: 10.7150/jca.94109. eCollection 2024.

Revisiting Temozolomide's role in solid tumors: Old is gold?

Dimitrios Matthaios  1 , Ioanna Balgkouranidou  2 , Konstantinos Neanidis  3 , Andreas Sofis  4 , Anastasia Pikouli  5 , Konstantinos Romanidis  6 , Aglaia Pappa  7 , Michael Karamouzis  8 , Anna Zygogianni  9 , Charalampos Charalampidis  10 , Paul Zarogoulidis  11 , George Rigas  12 , Alex Galanis  7
Affiliations
Review

Revisiting Temozolomide's role in solid tumors: Old is gold?

Dimitrios Matthaios et al. J Cancer. .

Abstract

Temozolomide is an imidazotetrazine with a long history in oncology especially for the high grade malignant glioma and metastatic melanoma. However, last year's new indications for its use are added. Its optimum pharmacodynamic profile, its ability to penetrate the blood-brain barrier, the existence of methylation of MGMT in solid tumors which enhances its efficacy, the identification of new agents that can overcome temozolomide's resistance, the promising role of temozolomide in turning immune cold tumors to hot ones, are leading to expand its use in other solid tumors, giving oncologists an additional tool for the treatment of advanced and aggressive neoplasms.

Keywords: solid tumors; temozolomide.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Frequency of MGMT promoter methylation in different solid tumors. Markus Christmann et al. Bernd Kaina O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry Biochim Biophys Acta. 2011 Dec;1816(2):179-90.
Figure 2
Figure 2
Strategies to overcome temozolomide's resistance.
Figure 3
Figure 3
Potential future role of temozolomide in turning immune “cold” tumors to “hot” ones.
See this image and copyright information in PMC

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