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. 2024 May 15:11:1377733.
doi: 10.3389/fsurg.2024.1377733. eCollection 2024.

Determinants of survival and recurrence in patients with stage I colorectal cancer

Alimohammad Bananzadeh #  1 , Mahshid Bahadori #  2 , Mohammad Mohammadianpanah  2 , Faramarz Pakravan  3 , Sara Shojaei-Zarghani  2 , Ali Reza Safarpour  2
Affiliations

Determinants of survival and recurrence in patients with stage I colorectal cancer

Alimohammad Bananzadeh et al. Front Surg. .

Abstract

Background: Due to the novel advanced screening methods, the number of patients diagnosed with stage I colorectal cancer (CRC) is increasing. This retrospective cohort study aimed to identify recurrence and survival risk factors of patients with stage I CRC after surgery.

Materials and methods: Patients with stage I CRC were evaluated, and their demographic and clinicopathologic variables were recorded. The log-rank test assessed the association of variables with overall survival (OS), recurrence-free survival (RFS), local recurrence, and distant metastasis.

Results: The median overall survival period was 51 months. The recurrence rate was 13.7%: 7.2% local and 9.3% distant recurrence. One-, two-, three-, and five-year RFS were 92%, 89%, 87%, and 83%, respectively, and OS were 96%, 93%, 90%, and 89%, respectively. Local and distant recurrence rates were higher in patients with higher tumor grades. Additionally, RFS and OS were worse in patients with higher tumor grades, and perforation was associated with worse OS.

Conclusions: The determinants of survival and recurrence identified in the present study can be used to improve patient outcomes by early diagnosis and appropriate management of high-risk patients.

Keywords: cohort studies; colorectal neoplasms; neoplasm metastasis; recurrence; survival.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The overall (A) and recurrence-free (B) survival of patients.
Figure 2
Figure 2
The effect of tumor grade on overall (A) and recurrence-free survival (B) and perforation on overall survival (C).
See this image and copyright information in PMC

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