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Review
. 2024 May;15(Suppl 2):315-321.
doi: 10.1007/s13193-024-01938-6. Epub 2024 Apr 26.

The Role of Neoadjuvant and Adjuvant Chemotherapy in Pancreatic Cancer

Govind Babu K  1 , Venkata Pradeep Babu Koyyala  2
Affiliations
Review

The Role of Neoadjuvant and Adjuvant Chemotherapy in Pancreatic Cancer

Govind Babu K et al. Indian J Surg Oncol. 2024 May.

Abstract

Pancreatic cancer is an aggressive malignancy. Recurrences are very high despite high-quality surgery necessitating adjuvant therapy. The evolution of adjuvant therapy took several decades and gradually evolved from single-agent chemotherapy to multi-agent chemotherapy. The two important agents that are active in pancreatic cancer are 5-fluorouracil and gemcitabine, and with several combinations showing better results in the subsequent trials, the most recent trial PRODIGE 24 shows a median survival of 54.4 months. The role of neoadjuvant therapy is still evolving in resectable cancers. The role of adjuvant radiotherapy is not well defined due to controversial results from historical trials.

Keywords: Adjuvant chemotherapy; Adjuvant radiotherapy; Neoadjuvant chemotherapy; Pancreatic cancer; Resectability.

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Conflict of interest statement

Conflict of InterestThe authors declare no competing interests.

References

    1. Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA: a cancer journal for clinicians. 68(1):7–30 - PubMed
    1. Strobel O, Neoptolemos J, Jaeger D, Buechler MW. Optimizing the outcomes of pancreatic cancer surgery. Nat Rev Clin Oncol. 2019;16(1):11–26. doi: 10.1038/s41571-018-0112-1. - DOI - PubMed
    1. Hackert T. Surgery for pancreatic cancer after neoadjuvant treatment. Annals of Gastroenterol Surg. 2018;2(6):413–418. doi: 10.1002/ags3.12203. - DOI - PMC - PubMed
    1. Varadhachary GR, Tamm EP, Abbruzzese JL, Xiong HQ, Crane CH, Wang H, Lee JE, Pisters PW, Evans DB, Wolff RA. Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol. 2006;13:1035–1046. doi: 10.1245/ASO.2006.08.011. - DOI - PubMed
    1. Lee ES, Lee JM. Imaging diagnosis of pancreatic cancer: a state-of-the-art review. World J Gastroenterol: WJG. 2014;20(24):7864. doi: 10.3748/wjg.v20.i24.7864. - DOI - PMC - PubMed

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