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Review
. 2023 Dec 26;2(4):350-364.
doi: 10.1002/mlf2.12101. eCollection 2023 Dec.

Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes

Yuhao Fu  1   2 , Qingyuan Dou  1   2 , Kornelia Smalla  3 , Yu Wang  1   2 , Timothy A Johnson  4 , Kristian K Brandt  5   6 , Zhi Mei  1   2   7 , Maoyuan Liao  1   2 , Syed A Hashsham  8   9 , Andreas Schäffer  10 , Hauke Smidt  11 , Tong Zhang  12 , Hui Li  8 , Robert Stedtfeld  9 , Hongjie Sheng  13 , Benli Chai  8 , Marko Virta  7 , Xin Jiang  1   2 , Fang Wang  1   2 , Yong-Guan Zhu  2   14   15 , James M Tiedje  8
Affiliations
Review

Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes

Yuhao Fu et al. mLife. .

Abstract

The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG-containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.

Keywords: One Health; antibiotic; antimicrobial resistance; gut microbiota; modulatory strategies.

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Figures

Figure 1
Figure 1
Transmission of ARGs and ARB in the animals, humans, and environment.
Figure 2
Figure 2
Factors affecting the patterns of antibiotic resistome in gut microbiome.
Figure 3
Figure 3
Strategies to combat gut antibiotic resistance from the levels of nation, community, person, and gut management.
See this image and copyright information in PMC

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