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. 2024 May 16:11:1323091.
doi: 10.3389/fmed.2024.1323091. eCollection 2024.

Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

Erliang Li #  1   2 , Jianshi Tan #  3 , Ke Xu  1 , Ying Pan  1 , Peng Xu  1
Affiliations

Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

Erliang Li et al. Front Med (Lausanne). .

Abstract

Objective: To report the trend changes of the prevalence, incidence, and disability-adjusted life years (DALYs) of knee osteoarthritis (KOA) according to age, sex, sociodemographic index (SDI), and income.

Methods: This analysis used estimates from the broader Global Burden of Disease (GBD) study 2019, which covered 201 countries from 1990 to 2019. National prevalence, incidence, and DALYs were shown by using ggplot2 and maps packages. Five-year intervals were used for age groupings. The Commonwealth and the World Bank income classifications were used for income grouping.

Results: Globally, there were ~364.58 million prevalent cases (females: 225.16 million), 29.51 million incident cases (females: 17.53 million), and 11.53 million DALYs (females: 7.09 million) due to KOA in 2019. The Western Pacific Region had a high endemicity of ~7,319.87 cases per 100,000 people (7.64%). Japan's prevalence rate (12,610.12 cases per 100,000 population) was 10 times that of Somalia (1,178.23) in 2019. In 200 countries (except the United Arab Emirates), the prevalence, incidence, and DALY rates of KOA in 2019 were higher among females than among males and increased with age up to the oldest age group. The prevalence was highest in the high-middle SDI countries, and the incidence and DALYs were highest in the middle SDI countries.

Conclusion: There was a large burden of KOA worldwide, with some notable intercountry variation. Some countries had 10 times the burden of other countries. Increasing population awareness regarding the prevalence, incidence, and DALYs of KOA with a focus on the population in the Western Pacific Region is needed, particularly for older females. informs health policy development, and contributes to improving the efficiency, equity, and effectiveness of healthcare systems.

Keywords: Global Burden of Disease; disability-adjusted life years (DALYs); incidence; knee osteoarthritis; prevalence.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
National prevalence of KOA. (A) Prevalence from 1990 to 2019. (B) Prevalence in 2019.
Figure 2
Figure 2
Line graphs of the global prevalence, incidence, and DALYs (green line) and the five countries with the highest (red line) and lowest rankings (blue line) of KOA, 1990–2019. (A) Prevalence. (B) Incidence. (C) DALYs.
Figure 3
Figure 3
Pie charts of the global prevalence, incidence, and DALYs by sex and different age bin ranges for KOA. (A) Global prevalence for both sexes in 2019. (B) Global incidence for both sexes in 2019. (C) Global DALYs for both sexes in 2019. (D) Global prevalence for both sexes from 1990 to 2019. (E) Global incidence for both sexes from 1990 to 2019. (F) Global DALYs for both sexes from 1990 to 2019. (G) Global prevalence among females in 2019. (H) Global incidence among females in 2019. (I) Global DALYs among females in 2019. (J) Global prevalence among females from 1990 to 2019. (K) Global incidence among females from 1990 to 2019. (L) Global DALYs among females from 1990 to 2019. (M) Global prevalence among males in 2019. (N) Global incidence among males in 2019. (O) Global DALYs among males in 2019. (P) Global prevalence among males from 1990 to 2019. (Q) Global incidence among males from 1990 to 2019. (R) Global DALYs among males from 1990 to 2019.
Figure 4
Figure 4
National sex differences in KOA in 2019. (A) Prevalence. (B) Incidence. (C) DALYs.
Figure 5
Figure 5
Prevalence, incidence, and DALYs of SDI and income among patients with KOA. (A) SDI in 2019. (B) SDI from 1990 to 2019. (C) Commonwealth income classifications in 2019. (D) Commonwealth income classifications from 1990 to 2019. (E) World Bank income classifications in 2019. (F) World Bank income classifications from 1990 to 2019.
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