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Case Reports
. 2024 Apr 15;10(4):101504.
doi: 10.1016/j.jvscit.2024.101504. eCollection 2024 Aug.

Aortobisiliac graft thrombosis in bacillus Calmette-Guérin disseminated infection with graft involvement

Affiliations
Case Reports

Aortobisiliac graft thrombosis in bacillus Calmette-Guérin disseminated infection with graft involvement

Lorenzo Ciofani et al. J Vasc Surg Cases Innov Tech. .

Abstract

Bacillus Calmette-Guérin (BCG), a live attenuated form of Mycobacterium bovis, is part of the therapy for non-muscle-invasive bladder cancer. Cases of vascular graft infection in the context of BCG dissemination are rarely reported in the literature. We report a case of a 77-year-old man, who underwent intravesical instillation of BCG approximately 10 years earlier and presented to our hospital with acute thrombosis of a previous aortobisiliac graft, which tested positive for BCG infection. Aortic graft infections due to BCG dissemination are rare, but possible, complications. A prompt and multidisciplinary approach is necessary.

Keywords: Aortic graft infection; Aortic graft thrombosis; BCG infection.

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Conflict of interest statement

None.

Figures

Fig 1
Fig 1
Computed tomography angiography (CTA) showing voluminous retroperitoneal abscess.
Fig 2
Fig 2
Computed tomography angiography (CTA) showing right groin mass causing fistulization toward the surface.
Fig 3
Fig 3
Intraoperative photograph showing in situ reconstruction with aortobifemoral graft of bovine pericardium.
Fig 4
Fig 4
Follow-up computed tomography angiography (CTA) 2 months after explantation and in situ reconstruction.

References

    1. Prescott S., Jackson A.M., Hawkyard S.J., Alexandroff A.B., James K. Mechanisms of action of intravesical bacille Calmette-Guérin: local immune mechanisms. Clin Infect Dis. 2000;31:S91–S93. - PubMed
    1. Palmier M., Monnot A., Tenière T., Cohen Q., Plissonnier D. Mycotic arterial aneurysm secondary to BCG intravesical instillation: a review. J Med Vasc. 2022;47:94–105. - PubMed
    1. Arsuffi S., Cambianica A., Di Filippo E., et al. “Vascular graft infections caused by Mycobacterium bovis BCG after BCG immunotherapy for non-muscle-invasive bladder cancer: case report and review of literature.”. J Clin Tuberc Other Mycobact Dis. 2023;31 - PMC - PubMed
    1. Babjuk M., Burger M., Capoun O., et al. European association of urology guidelines on non-muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ) Eur Urol. 2022;81:75–94. - PubMed
    1. Pérez-Jacoiste Asín M.A., Fernández-Ruiz M., López-Medrano F., et al. Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature. Medicine (Baltim) 2014;93:236–254. - PMC - PubMed

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