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Review
. 2025;32(1):87-110.
doi: 10.2174/0109298673312727240527064833.

Antimalarial Drug Discovery from Natural and Synthetic Sources

Nik Nur Solehah Fitri Nik Mohd Azam  1 , Shatrah Othman  2 , Yeun-Mun Choo  1
Affiliations
Review

Antimalarial Drug Discovery from Natural and Synthetic Sources

Nik Nur Solehah Fitri Nik Mohd Azam et al. Curr Med Chem. 2025.

Abstract

Malaria remains a significant global health threat despite extensive efforts aimed at its eradication. Numerous challenges persist in eliminating the disease, chief among them being the parasite's ability to mutate, resulting in drug resistance. The discovery of antimalarial drugs has relied on both phenotypic and target-based approaches. While phenotypic screening has identified promising candidates, target-based methods offer a more precise approach by leveraging chemically validated targets and computational tools. Analysis of Plasmodium spp . protein structures reveal druggable targets, offering opportunities for in silico screening. Combining compounds from natural and synthetic sources in a target-based approach accelerates the discovery of new antimalarial agents. This review explores previous breakthroughs in antimalarial drug discovery from natural products and synthetic origins, emphasizing their specific target proteins within Plasmodium species.

Keywords: Malaria; antimalarial; drug development; hypoglycemia.; natural products; target-based drug discovery.

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References

    1. Ali F.; Wali H.; Jan S.; Zia A.; Aslam M.; Ahmad I.; Afridi S.G.; Shams S.; Khan A.; Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria. Malar J 2021,20(1),335 - DOI - PubMed
    1. (MMV), M.f.M.V. Species of Plasmodium parasites infecting humans with malaria. Available from: https://www.mmv.org/malaria/species-plasmodium-parasites
    1. Pradhan S.; Hore S.; Roy S.; Manna S.; Dam P.; Mondal R.; Ghati A.; Biswas T.; Shaw S.; Sharma S.; Singh W.S.; Maji S.K.; Roy S.; Basu A.; Pandey K.C.; Samanta S.; Vashisht K.; Dolai T.K.; Kundu P.K.; Mitra S.; Biswas D.; Sadat A.; Shokriyan M.; Maity A.B.; Mandal A.K.; İnce İ.A.; Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria. Sci Rep 2023,13(1),14808 - DOI - PubMed
    1. Ministry of Health Malaysia: Management Guideline of Malaria in Malaysia. Available from: https://www.moh.gov.my/index.php/pages/view/1181
    1. Lai M.Y.; Rafieqin N.; Lee P.Y.L.; Amir Rawa M.S.; Dzul S.; Yahaya N.; Abdullah F.H.; Othman N.; Jelip J.; Ooi C.H.; Ibrahim J.; Aung M.; Abdullah A.H.; Laili Z.; Lau Y.L.; High incidence of Plasmodium knowlesi malaria compared to other human malaria species in several hospitals in Malaysia. Trop Biomed 2021,38(3),248-253 - DOI - PubMed

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