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. 2024 Jun;70(6):522-524.
doi: 10.1165/rcmb.2022-0487LE.

Neonatal Lung Mesenchymal Stromal Cells as Early Predictors of Post-prematurity Respiratory Disease

Affiliations

Neonatal Lung Mesenchymal Stromal Cells as Early Predictors of Post-prematurity Respiratory Disease

Danielle R Vanbeckum et al. Am J Respir Cell Mol Biol. 2024 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Comparisons of the proportions of patients with and without mesenchymal stromal cells (MSCs) in their tracheal aspirates in the first week of life who went on to develop post-prematurity respiratory disease (PPRD) and bronchopulmonary dysplasia (BPD) (Fisher exact test). (B) Receiver operating characteristic curves demonstrate the sensitivity and specificity of accurately identifying premature infants who go on to develop PPRD on the basis of the presence of MSCs in their tracheal aspirates in the first week of life or diagnosis of BPD, after controlling for days on mechanical ventilation, days receiving supplemental O2, and covariates. AUC = area under the curve.

References

    1. Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, et al. Bronchopulmonary Dysplasia Collaborative Interdisciplinary care of children with severe bronchopulmonary dysplasia. J Pediatr . 2017;181:12–28.e1. - PMC - PubMed
    1. Cristea AI, Ren CL, Amin R, Eldredge LC, Levin JC, Majmudar PP, et al. Outpatient respiratory management of infants, children, and adolescents with post-prematurity respiratory disease: an official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med . 2021;204:e115–e133. - PMC - PubMed
    1. Popova AP, Bozyk PD, Goldsmith AM, Linn MJ, Lei J, Bentley JK, et al. Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. Am J Physiol Lung Cell Mol Physiol . 2010;298:L735–L743. - PMC - PubMed
    1. Bozyk PD, Popova AP, Bentley JK, Goldsmith AM, Linn MJ, Weiss DJ, et al. Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression. Stem Cells Dev . 2011;20:1995–2007. - PMC - PubMed
    1. Popova AP, Bozyk PD, Bentley JK, Linn MJ, Goldsmith AM, Schumacher RE, et al. Isolation of tracheal aspirate mesenchymal stromal cells predicts bronchopulmonary dysplasia. Pediatrics . 2010;126:e1127–e1133. - PMC - PubMed

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