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. 1979 Sep-Oct;13(5):994-1000.

[Chemical modification of the complex of tRNA Phe with phenylalanyl-tRNA synthetase from Escherichia coli]

[Article in Russian]
V N Ankilova, V V Vlasov, S V Mamaev, N A Nuzhdina
  • PMID: 388193

[Chemical modification of the complex of tRNA Phe with phenylalanyl-tRNA synthetase from Escherichia coli]

[Article in Russian]
V N Ankilova et al. Mol Biol (Mosk). 1979 Sep-Oct.

Abstract

Alkylation of E. coli tRNAPhe, bound to the cognate synthetase was investigated. The alkylating reagent is a derivative of 2-chloroethylamine: 2',3'-O-[4(N-2-chloroethyl-N-methylamino)-benzylidene]-uridine-5'-methylphosphate. It was found that the enzyme protects from the reaction D-stem (guanosine G24) and the region of juxtaposition of acceptor stem and D-stem (S4U8 and C13) in the tRNAPhe.

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