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. 2024 Sep;55(3):1179-1189.
doi: 10.1007/s12029-024-01070-2. Epub 2024 May 31.

Racial/Ethnic Disparities in HRQoL and Associated Risk Factors in Colorectal Cancer Survivors: With a Focus on Social Determinants of Health (SDOH)

Claire J Han  1 , Fode Tounkara  2 , Matthew F Kalady  3 , Anne M Noonan  4 , Electra D Paskett  5 , Diane Von Ah  6
Affiliations

Racial/Ethnic Disparities in HRQoL and Associated Risk Factors in Colorectal Cancer Survivors: With a Focus on Social Determinants of Health (SDOH)

Claire J Han et al. J Gastrointest Cancer. 2024 Sep.

Abstract

Purpose: This study aimed to understand how health-related quality of life (HRQoL) differs by race/ethnicity in colorectal (CRC) survivors. We aimed to 1) examine racial/ethnic disparities in HRQoL, and 2) explore the roles of social determinants of health (SDOH) risk factors for HRQoL differ by racial/ethnic groups.

Methods: In 2,492 adult CRC survivors using Behavioral Risk Factor Surveillance System (BRFSS) survey data (from 2014 to 2021, excluding 2015 due to the absence of CRC data), we used the Centers for Disease Control and Prevention (CDC) HRQoL measure, categorized into "better" and "poor." Multivariate logistic regressions with prevalence risk (PR) were employed for our primary analyses.

Results: Compared with non-Hispanic Whites (NHW), non-Hispanic Blacks (NHB) (PR = 0.61, p = .045) and Hispanics (PR = 0.32, p < .001) reported worse HRQoL in adjusted models. In adjusted models, unemployed/retired and low-income levels were common risk factors for worse HRQoL across all comparison groups (NHW, NHB, non-Hispanic other races, and Hispanics). Other SDOH associated with worse HRQoL include divorced/widowed/never married marital status (non-Hispanic other races and Hispanics), living in rural areas (NHW and NHB), and low education levels (NHB and Hispanics). Marital status, education, and employment status significantly interacted with race/ethnicity, with the strongest interaction between Hispanics and education (PR = 2.45, p = .045) in adjusted models.

Conclusion: These findings highlight the need for culturally tailored interventions targeting modifiable factors (e.g., social and financial supports, health literacy), specifically for socially vulnerable CRC survivors, to address the disparities in HRQoL among different racial/ethnic groups.

Keywords: Cancer Survivorship; Colorectal Cancer; Health-Related Quality of Life; Healthy Equity; Social Determinants of Health.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. Ali H. Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures. Explor Med. 2021;2:455–67. 10.37349/emed.2021.00063.10.37349/emed.2021.00063 - DOI
    1. Carethers JM, Doubeni CA. Causes of socioeconomic disparities in colorectal cancer and intervention framework and strategies. Gastroenterol. 2020;158(2):354–67. 10.1053/j.gastro.2019.10.029.10.1053/j.gastro.2019.10.029 - DOI - PMC - PubMed
    1. Best AL, Roberson ML, Plascak JJ, Peterson CE, Rogers CR, Hastert TA, et al. Structural racism and cancer: Calls to action for cancer researchers to address racial/ethnic cancer inequity in the United States. Cancer Epidemiol Biomark Prev. 2022;31(6):1243–6. 10.1158/1055-9965.Epi-21-1179.10.1158/1055-9965.Epi-21-1179 - DOI - PMC - PubMed
    1. Nayak P, Paxton RJ, Holmes H, Thanh Nguyen H, Elting LS. Racial and ethnic differences in health behaviors among cancer survivors. Am J Prev Med. 2015;48(6):729–36. 10.1016/j.amepre.2014.12.015. 10.1016/j.amepre.2014.12.015 - DOI - PubMed
    1. Tramontano AC, Chen Y, Watson TR, Eckel A, Hur C, Kong CY. Racial/ethnic disparities in colorectal cancer treatment utilization and phase-specific costs, 2000–2014. PLoS ONE. 2020;15(4):e0231599. 10.1371/journal.pone.0231599. 10.1371/journal.pone.0231599 - DOI - PMC - PubMed

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