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. 2024 Jul;21(7):790-797.
doi: 10.1038/s41423-024-01168-4. Epub 2024 May 31.

Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies

Yufang Shi  1 , Andreas Strasser  2 , Douglas R Green  3 , Eicke Latz  4   5 , Alberto Mantovani  6 , Gerry Melino  7
Affiliations

Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies

Yufang Shi et al. Cell Mol Immunol. 2024 Jul.
No abstract available

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Conflict of interest statement

The authors declare no competing interests. YS and EL are editorial board members of Cellular & Molecular Immunology, but they have not been involved in the peer review or the decision-making of the article.

Figures

Fig. 1
Fig. 1
Jacques Miller and Max Cooper received the 2019 Lasker Basic Medical Research Award (Courtesy of Lasker Foundation)
Fig. 2
Fig. 2
Tak Wha Mak and Mark Davis in 1984 (Courtesy of Gerry Melino)
Fig. 3
Fig. 3
Structure and activation of the BCR and TCR complexes. A B cell antigen receptor complex; (B) T cell antigen receptor complex; (C) Interaction between a CD8+ T cell and a antigen presenting cell; (D) Interaction between a CD4+ T cell and a antigen presenting cell
See this image and copyright information in PMC

References

    1. Hedrick SM, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984;308:149–53. doi: 10.1038/308149a0. - DOI - PubMed
    1. Yanagi Y, Yoshikai Y, Leggett K, Clark SP, Aleksander I, Mak TW. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature. 1984;308:145–9. doi: 10.1038/308145a0. - DOI - PubMed
    1. Arnold T. In: Thucydides, History of the Peloponnesian War, Chapter VII, the Second Year of the War - The Plague of Athens - Position and Policy of Pericles Fall of Potidaea. Cambridge University Press; 1843. pp. 131–48.
    1. Temple R. The Genius of China: 3000 Years of Science, Discovery, and Invention. New York: Simon and Schuster, Inc. 1986. pp. 135–37.
    1. Moulin A-M. Le dernier langage de la médecine: histoire de l’immunologie, de Pasteur au Sida. Cambridge University Press; 1991. p. 24.

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