Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct;18(5):1052-1063.
doi: 10.1007/s11682-024-00897-4. Epub 2024 Jun 1.

Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis

Wenbo Yang #  1 , Mingan Li #  1 , Lijun Song  1 , Boyan Xu  2 , Qian Chen  1 , Zhenghan Yang  1 , Wenhu Liu  3 , Aihua Zhang  4 , Hao Wang  5 , Zhen-Chang Wang  6
Affiliations

Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis

Wenbo Yang et al. Brain Imaging Behav. 2024 Oct.

Abstract

Hemodialysis (HD) leads to cognitive impairment; however, the pathophysiology of maintenance HD remains unclear. This study aimed to investigate the longitudinal alterations in gray matter volume (GMV) and cerebral blood flow (CBF) in patients on HD at follow-up compared with baseline, examine the alterations in functional connectivity (FC) by defining co-changed brain regions as seed points, and investigate the correlation between the co-changed brain regions and neuropsychological test scores. Twenty-seven patients with HD and 30 healthy controls were enrolled in this study. All participants underwent high-resolution T1-weighted imaging, arterial spin labeling, and functional MR imaging to measure GMV, CBF, and FC. The patients on HD were assessed at baseline and 3 years subsequently. The right and left medial superior frontal gyrus (SFGmed.L) exhibited significantly lower GMV and CBF in patients on HD at follow-up compared with baseline and lower FC between the SFGmed.L and left middle temporal gyrus (MTG.L). FC between the SFGmed.L and MTG.L was positively correlated with neuropsychological test scores in the HD group at follow-up. Reduced GMV and CBF may result in decreased FC between the SFGmed.L and MTG.L, which may be associated with cognitive impairment in patients on maintenance HD. Our findings provide unique insights into the pathological mechanisms of patients on maintenance HD with cognitive impairment.

Keywords: Cerebral blood flow; Cognitive impairment; Functional connectivity; Gray matter volume; Hemodialysis.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethical approval: The study has been approved by the Ethics Committee of Beijing Friendship Hospital, Capital Medical University. The study was conducted following the Declaration of Helsinki. Consent to participate: Informed consent was obtained from all study participants. Legally Authorized Representatives of illiterate participants provided informed consent for the study. Consent to publication: All the authors agreed to publish this article. Competing interests: The authors declare no competing interests.

References

    1. Aminoff, E. M., Kveraga, K., & Bar, M. (2013). The role of the parahippocampal cortex in cognition. Trends in Cognitive Sciences, 17(8), 379–390. https://doi.org/10.1016/j.tics.2013.06.009 - DOI - PubMed - PMC
    1. Anazodo, U. C., Wong, D. Y., Théberge, J., Dacey, M., Gomes, J., Penny, J. D., . . . McIntyre, C. W. (2023). Hemodialysis-Related Acute Brain Injury Demonstrated by Application of Intradialytic Magnetic Resonance Imaging and Spectroscopy. Journal of the American Society of Nephrology: JASN, 34(6), 1090–1104. https://doi.org/10.1681/asn.0000000000000105
    1. Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. The neurobiology of semantic memory. Trends In Cognitive Sciences, 15(11), 527–536. https://doi.org/10.1016/j.tics.2011.10.001
    1. Binder, J. R., & Desai, R. H. (2011). The neurobiology of semantic memory. Trends In Cognitive Sciences, 15(11), 527–536. https://doi.org/10.1016/j.tics.2011.10.001
    1. Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009). Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cerebral Cortex, 19(12), 2767–2796. https://doi.org/10.1093/cercor/bhp055 - DOI - PubMed - PMC

MeSH terms

LinkOut - more resources