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Randomized Controlled Trial
. 2024 Aug;96(2):405-411.
doi: 10.1002/ana.26956. Epub 2024 Jun 1.

Add-On Deep Brain Stimulation versus Continued Vagus Nerve Stimulation for Childhood Epilepsy (ADVANCE): A Partially Randomized Patient Preference Trial

Hrishikesh Suresh  1   2   3 , Karim Mithani  1   2   3 , Nebras Warsi  1   2   3 , Ayako Ochi  4 , Hiroshi Otsubo  4 , James M Drake  3   5 , James T Rutka  3   5 , Elizabeth Kerr  4 , Mary Lou Smith  2   4 , Sara Breitbart  5 , Ivanna Yau  4 , Lyndsey McRae  4 , Vann Chau  4 , Shelly Weiss  4 , Puneet Jain  4 , Elizabeth Donner  4 , Alfonso Fasano  4   6   7   8   9 , Carolina Gorodetsky  4 , George M Ibrahim  1   2   3   5   6
Affiliations
Randomized Controlled Trial

Add-On Deep Brain Stimulation versus Continued Vagus Nerve Stimulation for Childhood Epilepsy (ADVANCE): A Partially Randomized Patient Preference Trial

Hrishikesh Suresh et al. Ann Neurol. 2024 Aug.

Abstract

Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug-resistant epilepsy. The added value of deep brain stimulation (DBS) instead of continued VNS optimization is unknown. In a prospective, non-blinded, randomized patient preference trial of 18 children (aged 8-17 years) who did not respond to VNS after at least 1 year, add-on DBS resulted in greater seizure reduction compared with an additional year of VNS optimization (51.9% vs. 12.3%, p = 0.047). Add-on DBS also resulted in less bothersome seizures (p = 0.03), but no change in quality of life. DBS may be considered earlier for childhood epilepsy after non-response to VNS. ANN NEUROL 2024;96:405-411.

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