Review

. 2024 Jun 1.

doi: 10.1007/s10557-024-07578-w. Online ahead of print.

Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases

Chang Di^{1

2

3

4

5}, Meng Ji^{6

7

8

9

10}, Wenjin Li^{6

7

8

9

10}, Xiaoyi Liu^{6

7

8

9

10}, Rijan Gurung¹¹, Boyang Qin^{6

7

8

9

10}, Shu Ye¹¹, Rong Qi^{12

13

14

15

16

17}

Affiliations

¹ Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, Haidian District, China. dichang@pku.edu.cn.
² State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
³ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
⁴ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
⁵ Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
⁶ Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, Haidian District, China.
⁷ State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China.
⁸ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
⁹ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China.
¹⁰ Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China.
¹¹ Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore.
¹² Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, Haidian District, China. ronaqi@bjmu.edu.cn.
¹³ State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁴ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁵ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁶ Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁷ Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. ronaqi@bjmu.edu.cn.

PMID: 38822974
DOI: 10.1007/s10557-024-07578-w

Review

Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases

Chang Di et al. Cardiovasc Drugs Ther. 2024.

. 2024 Jun 1.

doi: 10.1007/s10557-024-07578-w. Online ahead of print.

Authors

Affiliations

¹ Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, Haidian District, China. dichang@pku.edu.cn.
² State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
³ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
⁴ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
⁵ Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China. dichang@pku.edu.cn.
⁶ Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, Haidian District, China.
⁷ State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China.
⁸ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
⁹ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China.
¹⁰ Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China.
¹¹ Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore.
¹² Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, Haidian District, China. ronaqi@bjmu.edu.cn.
¹³ State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁴ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁵ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁶ Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China. ronaqi@bjmu.edu.cn.
¹⁷ Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. ronaqi@bjmu.edu.cn.

PMID: 38822974
DOI: 10.1007/s10557-024-07578-w

Abstract

Vascular remodeling is the adaptive response of the vessel wall to physiological and pathophysiological changes, closely linked to vascular diseases. Vascular smooth muscle cells (VSMCs) play a crucial role in this process. Pyroptosis, a form of programmed cell death characterized by excessive release of inflammatory factors, can cause phenotypic transformation of VSMCs, leading to their proliferation, migration, and calcification-all of which accelerate vascular remodeling. Inhibition of VSMC pyroptosis can delay this process. This review summarizes the impact of pyroptosis on VSMCs and the pathogenic role of VSMC pyroptosis in vascular remodeling. We also discuss inhibitors of key proteins in pyroptosis pathways and their effects on VSMC pyroptosis. These findings enhance our understanding of the pathogenesis of vascular remodeling and provide a foundation for the development of novel medications that target the control of VSMC pyroptosis as a potential treatment strategy for vascular diseases.

Keywords: Pyroptosis; VSMC; Vascular diseases; Vascular remodeling.

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Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases

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Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases

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