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. 1979 May;7(5):511-3.
doi: 10.1111/j.1365-2125.1979.tb00995.x.

The gastrointestinal absorption of PRD-92 Ea, a new anti-allergy drug

A J Johnson, J L Beets

The gastrointestinal absorption of PRD-92 Ea, a new anti-allergy drug

A J Johnson et al. Br J Clin Pharmacol. 1979 May.

Abstract

1 The absorption of PRD-92 Ea, a new anti-allergy drug, was studied in volunteer subjects. 2 The 14C-labelled drug was administered orally and the radioactivity measured in plasma, urine and faeces. 3 Mean peak plasma concentration was 3.3 micrograms/ml, with a concentration of over 1 micrograms/ml maintained 4 h after administration. 4 The mean plasma half-life (T 1/2) was 114 min. 5 The mean percentage recovery in the urine was 9.5%. 6 Oral administration leads to significant and sustained plasma concentrations, and the oral route should be suitable for drug evaluation in clinical practice.

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References

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    1. Int Arch Allergy Appl Immunol. 1977;55(1-6):343-9 - PubMed
    1. J Pharm Pharmacol. 1972 Jul;24(7):525-31 - PubMed
    1. Int Arch Allergy Appl Immunol. 1977;55(1-6):350-61 - PubMed
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