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. 2024 Aug:395:117587.
doi: 10.1016/j.atherosclerosis.2024.117587. Epub 2024 May 17.

Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study

J Sebastian Miranda Maravi  1 , Eric C Leszczynski  1 , Charles S Schwartz  1 , Prasun K Dev  1 , Jacob L Barber  2 , Riley J Reasons  1 , Ryan W Pearce  3 , Michael J McPhaul  3 , Robert J Konrad  4 , Jeremy M Robbins  5 , Robert E Gerszten  5 , Timothy S Collier  3 , Claude Bouchard  6 , Anand Rohatgi  7 , Mark A Sarzynski  8
Affiliations

Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study

J Sebastian Miranda Maravi et al. Atherosclerosis. 2024 Aug.

Abstract

Background and aims: Previous studies have derived and validated an HDL apolipoproteomic score (pCAD) that predicts coronary artery disease (CAD) risk. However, the associations between pCAD and markers of cardiometabolic health in healthy adults are not known, nor are the effects of regular exercise on pCAD.

Methods: A total of 641 physically inactive adults free of cardiovascular disease from the HERITAGE Family Study completed 20 weeks of exercise training. The pCAD index (range 0-100) was calculated using measurements of apolipoproteins A-I, C-I, C-II, C-III, and C-IV from ApoA-I-tagged serum (higher index = higher CAD risk). The associations between pCAD index and cardiometabolic traits at baseline and their training responses were assessed with Spearman correlation and general linear models. A Bonferroni correction of p < 8.9 × 10-04 was used to determine statistical significance.

Results: The mean ± SD baseline pCAD index was 29 ± 32, with 106 (16.5 %) participants classified as high CAD risk. At baseline, pCAD index was positively associated with blood pressure, systemic inflammation, and body composition. HDL size, VO2max, and HDL-C were negatively associated with pCAD index at baseline. Of those classified as high CAD risk at baseline, 52 (49 %) were reclassified as normal risk after training. Following training, pCAD index changes were inversely correlated (p < 1.4 × 10-04) with changes in HDL-C, HDL size, and LDL size.

Conclusions: A higher pCAD index was associated with a worse cardiometabolic profile at baseline but improved with regular exercise. The results from this study highlight the potential role of HDL apolipoproteins as therapeutic targets for lifestyle interventions, particularly in high-risk individuals.

Keywords: Biomarker; Coronary artery disease; High-density lipoprotein; Proteomics; pCAD.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mark A. Sarzynski reports financial support was provided by National Institutes of Health. Robert E. Gerszten reports a relationship with National Institutes of Health that includes: funding grants. J. Sebastian Miranda Maravi reports a relationship with National Institutes of Health that includes: funding grants. Jacob L. Barber reports a relationship with National Institutes of Health that includes: funding grants. Ryan W. Pearce reports a relationship with Quest Diagnostics that includes: employment and equity or stocks. Michael J. McPhaul reports a relationship with Quest Diagnostics that includes: employment and equity or stocks. Timothy S. Collier reports a relationship with Quest Diagnostics that includes: employment and equity or stocks. Robert J. Konrad reports a relationship with Eli Lilly and Company that includes: employment and equity or stocks. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
Change in pCAD index in response to exercise training across baseline pCAD index quartiles. Mean values are adjusted for age, sex, and race, with error bars representing standard error of the least squares means. *p<0.05 for change from baseline within quartile group. Different letters represent p<0.05 for mean differences between baseline pCAD index quartile groups.
Figure 2.
Figure 2.
Association of pCAD index with cardiometabolic traits at baseline and after exercise training in the HERITAGE Family Study
See this image and copyright information in PMC

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