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Review
. 2024 Jun 1;51(1):717.
doi: 10.1007/s11033-024-09588-1.

Aerobic glycolysis of vascular endothelial cells: a novel perspective in cancer therapy

Shenhao Xu #  1 , Jiahao Liao #  1 , Bing Liu #  1 , Cheng Zhang  2 , Xin Xu  3
Affiliations
Review

Aerobic glycolysis of vascular endothelial cells: a novel perspective in cancer therapy

Shenhao Xu et al. Mol Biol Rep. .

Abstract

Vascular endothelial cells (ECs) are monolayers of cells arranged in the inner walls of blood vessels. Under normal physiological conditions, ECs play an essential role in angiogenesis, homeostasis and immune response. Emerging evidence suggests that abnormalities in EC metabolism, especially aerobic glycolysis, are associated with the initiation and progression of various diseases, including multiple cancers. In this review, we discuss the differences in aerobic glycolysis of vascular ECs under normal and pathological conditions, focusing on the recent research progress of aerobic glycolysis in tumor vascular ECs and potential strategies for cancer therapy.

Keywords: Aerobic glycolysis; Cancer; Therapy; Vascular endothelial cells.

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Conflict of interest statement

The authors declare no conflict of interest. This study did not involve Human Participants and/or Animals. All authors have read and agreed to the published version of the manuscript.

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Hypoxia and HIF signaling in angiogenic function of TECs
See this image and copyright information in PMC

References

    1. Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473(7347):298–307 Epub 2011/05/20. doi: 10.1038/nature10144. PubMed PMID: 21593862; PubMed Central PMCID: PMCPMC4049445 - PMC - PubMed
    1. Potente M, Gerhardt H, Carmeliet P (2011) Basic and therapeutic aspects of angiogenesis. Cell 146(6):873–887 Epub 2011/09/20. 10.1016/j.cell.2011.08.039 - PubMed
    1. Phng LK, Gerhardt H (2009) Angiogenesis: a team effort coordinated by notch. Dev Cell 16(2):196–208 Epub 2009/02/17. 10.1016/j.devcel.2009.01.015 - PubMed
    1. Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM et al (2010) Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol 12(10):943–953 Epub 2010/09/28. 10.1038/ncb2103 - PubMed
    1. Förstermann U, Sessa WC (2012) Nitric oxide synthases: regulation and function. Eur Heart J 33(7):829–837 837a-837d. Epub 2011/09/06. 10.1093/eurheartj/ehr304 - PMC - PubMed