Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 1;24(1):668.
doi: 10.1186/s12885-024-12454-9.

The TEOGIC study project: a comprehensive characterization of early onset gastrointestinal cancer in the Northern area of Spain

R Vera  1   2 , N Castro  1 , I Labiano  1 , A Lecumberri  1   2 , A E Huerta  1 , H Arasanz  1   2 , I Caseda  1 , F Ruiz-Pace  3 , C Viaplana  3 , V Arrazubi  1   2 , I Hernandez-Garcia  1   2 , E Mata  1   2 , D Gomez  1   2 , S Laguna  2 , J Suarez  4 , I Fernandez-De-Los-Reyes  5   6 , M Rullan  7   8 , F Estremera  7 , V Alonso  9 , R Pazo-Cid  9 , A Gil-Negrete  10 , A Lafuente  11 , A Martin-Carnicero  11 , R Dienstmann  3   12 , M Alsina  13   14
Affiliations

The TEOGIC study project: a comprehensive characterization of early onset gastrointestinal cancer in the Northern area of Spain

R Vera et al. BMC Cancer. .

Erratum in

Abstract

Background: Gastrointestinal cancers represent one of the most prevalent diseases worldwide. Strikingly, the incidence of Early Onset Gastrointestinal Cancer (EOGIC) has been rising during the last decades and changes in lifestyle and environmental exposure seem to play a role. EOGIC has been defined as a different entity compared to on-average gastrointestinal cancer, with distinct clinical and molecular characteristics. Inherent to the particularities of younger age, there is an unmet need for a tailored approach for the management of these patients. The TEOGIC proposes a comprehensive study to characterize EOGIC patients in the northern of Spain.

Methods: Patients with histologically confirmed new diagnosis of colorectal, gastroesophageal and pancreatic adenocarcinoma will be considered for two cohorts: EOGIC (≤ 50 years old) and non-EOGIC (60-75 years old), with a ratio of 1:2. Two hundred and forty patients will be recruited in 4 Public Hospitals from northern Spain. After receiving unified informed consent, demographic and clinical data of the patients will be collected in a REDCap database. Lifestyle related data will be obtained in questionnaires assessing diet, physical activity and the general quality of life of the patients before diagnosis. Biological samples prior to any onco-specific treatment will be obtained for the analyses of circulating inflammatory proteins, gut microbiota, and the proteome of the tumor microenvironment. Histologic characteristics and routine biomarkers will be also collected. Thereafter, data will be integrated and analyzed to assess tumor specific, pan-tumor and sex-associated differential characteristics of EOGIC.

Discussion: The underlying risk factors and differential characteristics of EOGIC remain poorly studied, particularly in our geographical area. Although limited by the exploratory nature and the small sample size estimated to be recruited, TEOGIC represents the first attempt to comprehensively characterize these young patients, and thus attend to their special needs. Findings derived from this study could contribute to raise awareness and preventive behaviors in the population. In parallel, molecular studies could lead to the identification of potential novel non-invasive biomarkers and therapeutic targets that would help in the development of the tailored clinical management of these patients, focusing on screening programs for early diagnosis and precision medicine.

Keywords: Colorectal cancer; Early onset gastrointestinal cancer; Environmental risk factors; Gastroesophageal cancer; Gastrointestinal cancer; Microbiome; Pancreatic cancer; Precision medicine; Tumor microenvironment.

PubMed Disclaimer

Conflict of interest statement

RV has been involved as a consultant for advisory roles with Servier, Roche and Merck Sharp and has received speaker honoraria from Roche, Amgen, Merck Sharp and Dohme, Astra Zeneca. IL, NC, AEH, IC, FRP, CV, DG, JS, IFR, MR, FE, AGN, AL, VA, RPC and SL declare no conflict of interest. AL has received speaker honoraria from Pierre-Fabre. HA has been involved as a consultant for advisory roles from Astra Zeneca and for trial coordination from Ferrer Farma and received speaker honoraria from Takeda. VA has been involved as a consultant for advisory roles and received speaker honoraria from MSD, Bristol, Lilly, Astra-Zeneca and Pierre-Fabre. IHG has received speaker honoraria from Astra Zeneca. EM has been involved as a consultant for advisory roles with Servier, Roche and Merck Sharp and Dohme. RD declares advisory role for Roche, Foundation Medicine, received a speaker’s fee from Roche, Ipsen, Amgen, Servier, Sanofi, Libbs, Merck Sharp & Dohme, Lilly, AstraZeneca, Janssen, Takeda, Bristol Myers Squibb, GlaxoSmithKline, Gilead, research grants from Merck, Novartis, Daiichi-Sankyo, GlaxoSmithKline and AstraZeneca, and is investor in Trialing Health, S.L. AMC declares advisory role for Servier, Novartis, Pharmamar and Bristol Myers Squibb, received speaker honoraria from Novartis, Roche, Merck Sharp and Dohme, Merck, Pierre Fabre, Amgen, Sanofi, Servier and Bristol Myers Squib. MA has been involved as a consultant for advisory roles with Amgen, BMS, MSD, Lilly and Servier.

Figures

Fig. 1
Fig. 1
Estimated patient recruitment. a Diagram of the recruiting centers and estimated number of patients to be recruited by group. b Number of cases with GI cancer treated in Medical Oncology Unit of the HUN in the years 2019–2022. Red depicts EOGIC, while green depicts non-EOGIC (age > 50 years) CRC: colorectal cancer; EOGIC: early onset gastrointestinal cancer. GEC: gastroesophageal cancer; PC: pancreatic cancer
Fig. 2
Fig. 2
General diagram of the study. Diagram summarizing patient recruitment criteria and data to be recorded in the TEOGIC study. EOGIC: early onset gastrointestinal cancer; ECOG: Eastern Cooperative Oncology Group
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. (SEOM) SEdOM. Las Cifras del Cancer en España 2024. https://seom.org/ejercicio-contra-el-cancer/las-cifras-del-cancer-en-esp.... Available from: https://www.seom.org/images/LAS_CIFRAS_2024.pdf.
    1. Siegel RL, Torre LA, Soerjomataram I, Hayes RB, Bray F, Weber TK, et al. Global patterns and trends in colorectal cancer incidence in young adults. Gut. 2019;68(12):2179–2185. doi: 10.1136/gutjnl-2019-319511. - DOI - PubMed
    1. Araghi M, Soerjomataram I, Bardot A, Ferlay J, Cabasag CJ, Morrison DS, et al. Changes in colorectal cancer incidence in seven high-income countries: a population-based study. Lancet Gastroenterol Hepatol. 2019;4(7):511–518. doi: 10.1016/S2468-1253(19)30147-5. - DOI - PMC - PubMed
    1. Sung H, Siegel RL, Rosenberg PS, Jemal A. Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry. Lancet Public Health. 2019;4(3):e137–e147. doi: 10.1016/S2468-2667(18)30267-6. - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources