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. 2024 Jun 1;24(2):192-199.

Effects of Combined Application of Percutaneous Vertebroplasty and Zoledronic Acid on Bone Mineral Density, Bone Metabolism, NPY and PGE2 in Elderly Patients with Osteoporotic Lumbar Vertebral Compression Fracture

Huajie Wu  1 , Jiamin Zhu  1 , Gang Yu  1 , Lijun Yu  1
Affiliations

Effects of Combined Application of Percutaneous Vertebroplasty and Zoledronic Acid on Bone Mineral Density, Bone Metabolism, NPY and PGE2 in Elderly Patients with Osteoporotic Lumbar Vertebral Compression Fracture

Huajie Wu et al. J Musculoskelet Neuronal Interact. .

Abstract

Objective: To investigate the effects of the combined application of percutaneous vertebroplasty and zoledronic acid on bone mineral density (BMD), bone metabolism, neuropeptide Y (NPY) and prostaglandin E2 (PGE2) in elderly patients with osteoporotic lumbar vertebral compression fracture (OVCF).

Methods: The medical records of 118 elderly patients with OVCF who received treatment at our hospital from March 2018 to March 2020 were collected and analyzed retrospectively. Vertebral body height, spinal function, pain degree, and lumbar BMD were compared between the two groups upon admission and three years after the operation. Additionally, the levels of bone-specific alkaline phosphatase (BALP), 25-hydroxyvitamin D (25-(OH)D), beta collagen degradation fragments (β-CTx), neuropeptide Y (NPY), and prostaglandin E2 (PGE2) in the two groups were measured at admission and three years after the operation. Furthermore, complications in the two groups within three years after the operation were documented.

Results: After three years post-operation, the combination group showed a significantly greater improvement in vertebral body height compared to the control group (P<0.05). Moreover, the combination group exhibited a significantly lower Oswestry Disability Index (ODI) score compared to the control group (P<0.05).

Conclusion: In elderly patients with OVCF, the combined use of zoledronic acid and percutaneous vertebroplasty is effective in improving lumbar function, BMD, and bone metabolism indices, while reducing pain and the levels of NPY and PGE2.

Keywords: Bone Metabolism; Osteoporotic Lumbar Vertebral Compression Fracture; Percutaneous Vertebroplasty; Zoledronic Acid.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Study Flow chart.
Figure 2
Figure 2
Comparison in the levels of bone metabolism indices between the two groups. A: Changes of BALP level between the two groups before and after operation. B: Changes of (25-OH)D level between the two groups before and after operation. C: Changes of β-CTx level between the two groups before and after operation.
Figure 3
Figure 3
Comparison in the levels of NPY and PGE2 between the two groups. A: Changes of NPY level between the two groups before and after operation. B: Changes of PGE2 level between the two groups before and after operation.
See this image and copyright information in PMC

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References

    1. Li G, Thabane L, Papaioannou A, Ioannidis G, Levine MA, Adachi JD. An overview of osteoporosis and frailty in the elderly. BMC Musculoskelet Disord. 2017;18:46. - PMC - PubMed
    1. Alsoof D, Anderson G, McDonald CL, Basques B, Kuris E, Daniels AH. Diagnosis and Management of Vertebral Compression Fracture. Am J Med. 2022;135:815–821. - PubMed
    1. Kutsal FY, Ergin Ergani GO. Vertebral compression fractures:Still an unpredictable aspect of osteoporosis. Turk J Med Sci. 2021;51:393–399. - PMC - PubMed
    1. European Prospective Osteoporosis Study G. Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA, Finn JD, Cockerill WC, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, Cannata JB, Cooper C, Dequeker J, Eastell R, Felsch B, Gowin W, Havelka S, Hoszowski K, Jajic I, Janott J, Johnell O, Kanis JA, Kragl G, Lopes Vaz A, Lorenc R, Lyritis G, Masaryk P, Matthis C, Miazgowski T, Parisi G, Pols HA, Poor G, Raspe HH, Reid DM, Reisinger W, Schedit-Nave C, Stepan JJ, Todd CJ, Weber K, Woolf AD, Yershova OB, Reeve J, O'Neill TW. Incidence of vertebral fracture in europe:results from the European Prospective Osteoporosis Study (EPOS) J Bone Miner Res. 2002;17:716–724. - PubMed
    1. Svensson HK, Olsson LE, Hansson T, Karlsson J, Hansson-Olofsson E. The effects of person-centered or other supportive interventions in older women with osteoporotic vertebral compression fractures-a systematic review of the literature. Osteoporos Int. 2017;28:2521–2540. - PMC - PubMed