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Review
. 2024 May;13(2):89-96.
doi: 10.12997/jla.2024.13.2.89. Epub 2023 Dec 7.

The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial

Bambang Dwiputra  1 , Ade Meidian Ambari  1 , Dwita Rian Desandri  1 , Budhi Setianto Purwowiyoto  1 , Basuni Radi  1 , Bashar Adi Wahyu Pandhita  1 , Serlie Fatrin  1 , Anwar Santoso  1
Affiliations
Review

The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial

Bambang Dwiputra et al. J Lipid Atheroscler. 2024 May.

Erratum in

  • Corrigendum to Previously Published Articles.
    Editorial Office of the Journal of Lipid and Atherosclerosis. Editorial Office of the Journal of Lipid and Atherosclerosis. J Lipid Atheroscler. 2025 Jan;14(1):132-133. doi: 10.12997/jla.2025.14.1.132. Epub 2025 Jan 14. J Lipid Atheroscler. 2025. PMID: 39911960 Free PMC article.

Abstract

The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84-1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88-1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.

Keywords: Atherosclerosis; Cardiovascular disease; Omega-3 fatty acid; Secondary prevention.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1. Mortality rate omega-3 compared with control.
GISSI-HF, Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure; ORIGIN, Outcome Reduction with an Initial Glargine Intervention; MH, Mantel-Haenszel; CI, confidence interval.
Fig. 2
Fig. 2. Hospitalization rate receiving omega 3 compared to control.
MH, Mantel-Haenszel; CI, confidence interval; GISSI-HF, Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure; ORIGIN, Outcome Reduction with an Initial Glargine Intervention; VITAL-HF, Vitamin D and Omega-3 Trial-Heart Failure.
See this image and copyright information in PMC

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