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Case Reports
. 2024 May 1;16(5):e59490.
doi: 10.7759/cureus.59490. eCollection 2024 May.

Perioperative Use of Levosimendan in Hepatic Transplantation With Diastolic Heart Failure: A Case Report

Affiliations
Case Reports

Perioperative Use of Levosimendan in Hepatic Transplantation With Diastolic Heart Failure: A Case Report

Erick Villafán Vázquez et al. Cureus. .

Abstract

Levosimendan is a medication with a range of pharmacological effects, making it appropriate for use in several clinical settings, including advanced heart failure with pulmonary hypertension, cardiogenic shock, and acute heart failure. This case report details the perioperative management of a male in their 40s with a complex medical history, including primary hypoparathyroidism, cirrhosis, and severe pulmonary hypertension, who underwent urgent cadaveric donor liver transplantation. Information available on the perioperative use of levosimendan is still insufficient to be able to regulate behaviors that can guide its management on a regular basis.

Keywords: anesthesia; heart failure; levosimendan; perioperative anesthesia; transplant.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Anesthesia management for hepatic transplantation

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References

    1. Levosimendan for perioperative cardioprotection: myth or reality? Santillo E, Migale M, Massini C, Incalzi RA. Curr Cardiol Rev. 2018;14:142–152. - PMC - PubMed
    1. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Ponikowski P, Voors AA, Anker SD, et al. Eur Heart J. 2016;37:2129–2200. - PubMed
    1. Levosimendan vs. dobutamine: outcomes for acute heart failure patients on beta-blockers in SURVIVE. Mebazaa A, Nieminen MS, Filippatos GS, et al. Eur J Heart Fail. 2009;11:304–311. - PMC - PubMed
    1. The perioperative use of levosimendan as a means of optimizing the surgical outcome in patients with severe heart insufficiency undergoing cardiac surgery. Leivaditis V, Grapatsas K, Papaporfyriou A, et al. J Cardiovasc Dev Dis. 2023;10 - PMC - PubMed
    1. Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion. Toller W, Heringlake M, Guarracino F, et al. Int J Cardiol. 2015;184:323–336. - PubMed

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