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Case Reports
. 2024 May 17:12:1397456.
doi: 10.3389/fped.2024.1397456. eCollection 2024.

Case Report: Micafungin for treating Candida glabrata urinary infection: a clinical case in a premature neonate

Carlos Javier Parramon-Teixido  1 , Carme Garcia Esquerda  1 , Marie Antoinette Frick  2 , Cinzia Tripodi  3 , Laura Gomez-Ganda  1 , Cesar Wenceslao Ruiz-Campillo  4 , Maria Josep Cabañas-Poy  1
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Case Reports

Case Report: Micafungin for treating Candida glabrata urinary infection: a clinical case in a premature neonate

Carlos Javier Parramon-Teixido et al. Front Pediatr. .

Abstract

Urinary tract infections (UTIs) associated with indwelling urinary catheterization (IUC) in premature newborns (PNBs) pose a significant challenge in neonatal intensive care units (NICUs) due to the vulnerability of this population to infections and the necessity of invasive procedures. While bacterial UTIs have historically been predominant, there is a rising incidence of fungal pathogens, particularly non-albicans Candida strains like Candida glabrata and Candida tropicalis, attributed to broad-spectrum antibiotic use. Diagnosis of fungal UTIs in a PNB relies on culturing Candida spp. from properly collected urine samples, particularly critical in very low birth weight (VLBW) PNBs because of the risk of invasive candidiasis and associated complications. We present a case of an extremely premature newborn (EPNB) successfully treated for a UTI caused by C. glabrata with micafungin. Our case exhibits micafungin as a potentially safe and effective alternative for treating C. glabrata UTIs in neonates.

Keywords: Candida glabrata; case report; micafungin; premature infant; urinary tract infection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Sequence of events of the patient. BC, blood culture; CFU, colony-forming unit; DOL, day of life; IUC, indwelling urinary catheter; UC, urine culture; US, urine sediment; UTI, urinary tract infection.
See this image and copyright information in PMC

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