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. 2024 Mar 14:11:200101.
doi: 10.1016/j.jpedcp.2024.200101. eCollection 2024 Mar.

Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years' Corrected Age in Infants Born Very Preterm

Katsuaki Kojima  1   2 , Julia E Kline  1 , Mekibib Altaye  1   2   3 , Beth M Kline-Fath  1   4 , Nehal A Parikh  1   2 ; Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators
Collaborators, Affiliations

Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years' Corrected Age in Infants Born Very Preterm

Katsuaki Kojima et al. J Pediatr Clin Pract. .

Abstract

We studied the effect of microstructural abnormalities in the corpus callosum on language development in 348 infants born very prematurely. We discovered that the fractional anisotropy of the corpus callosum anterior midbody was a significant predictor of standardized language scores at 2 years, independent of clinical and social risk factors.

Keywords: Bayley-III; corpus callosum; diffusion tensor imaging; infant; language; neurodevelopmental outcome; newborn; preterm.

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Conflict of interest statement

Supported by the 10.13039/100000002National Institutes of Health from the 10.13039/100000065National Institute of Neurological Disorders and Stroke (R01-NS094200, R01-NS096037, and R01-EB029944) to N.P. and from the 10.13039/100006108National Center for Advancing Translational Sciences (2UL1TR001425-05A1) to K.K. The authors have no conflicts of interest to disclose.

Figures

Figure
Figure
Tractography of CC subregions. Axial views of all CC subregions are shown in A, whereas sagittal views are depicted in B. C, Sagittal view with color coding to differentiate each subregion: red for the rostrum, green for the genu, blue for the rostral body, orange for the anterior midbody, purple for the posterior midbody, yellow for the isthmus, and pink for the splenium. D-J, Axial orientation of individual subregions: the rostrum (D), genu (E), anterior midbody (F), rostral body (G), posterior midbody (H), isthmus (I), and splenium (J), respectively. CC, corpus callosum.
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