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. 2024 Jan-Mar;49(1):1-5.
doi: 10.4103/jmp.jmp_79_23. Epub 2024 Mar 30.

Program for Determining the Dosimetric Contribution of Tc-99m Biokinetics in Estimating the Dose to the Heart of a Male Adult

Rosa Adela Morales-Nizama  1 , Moisés Miguel Gallozzo-Cárdenas  2 , Héctor Almanzor Chinchay-Espino  1 , Emzon Murga-Torres  3 , Amilu M Alvarez-Escobedo  4 , Renny Nazario-Naveda  5
Affiliations

Program for Determining the Dosimetric Contribution of Tc-99m Biokinetics in Estimating the Dose to the Heart of a Male Adult

Rosa Adela Morales-Nizama et al. J Med Phys. 2024 Jan-Mar.

Abstract

Purpose: To calculate the contribution of absorbed dose by organs in the biokinetics of Tc-99m when used for radiodiagnosis of the adult male heart employing a Matlab program.

Methods: The absorbed self-dose of the adult male heart and absorbed dose by organs in the biokinetics of the heart when administering Tc-99m are estimated using the MIRD formalism and the Cristy-Eckerman representation, which have been employed to develop the algorithm in Matlab.

Results: The results indicate that electron capture emissions of 1.446 (mGy/MBq) and Auger electrons of 0.062 (mGy/MBq) are entirely directed towards the target organ (heart) and contribute 29.33% and 1.25% respectively to its total dose. Additionally, the dosimetric contributions of biokinetic organs correspond to characteristic radiation emissions and gamma photons at 2.578 (mGy/MBq) for Tc-99m, representing 52.29% of its total dose.

Conclusion: These dosimetric contributions are significant in estimating the total absorbed dose by the heart in adult males and should not be disregarded.

Keywords: Biokinetics; Tc-99m; internal dosimetry; medical internal radiation dose formalism.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
The flowchart that summarizes the MATLAB algorithm
Figure 2
Figure 2
Flowchart to calculate the absorbed dose per unit of total activity
Figure 3
Figure 3
Absorbed dose versus Snyder factor
See this image and copyright information in PMC

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