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. 2024 May 27:17:1941-1951.
doi: 10.2147/JPR.S457575. eCollection 2024.

The Duration of Chronic Pain Can Affect Brain Functional Changes of the Pain Matrix in Patients with Chronic Back Pain: A Resting-State fMRI Study

Yingxuan Hu #  1 , Junqin Ma #  1 , Bingmei Chen  2 , Jiahui Pang  1 , Wen Liang  2 , Wen Wu  1
Affiliations

The Duration of Chronic Pain Can Affect Brain Functional Changes of the Pain Matrix in Patients with Chronic Back Pain: A Resting-State fMRI Study

Yingxuan Hu et al. J Pain Res. .

Abstract

Purpose: This study was conducted to explore the differences in functional changes in the pain matrix in patients with chronic back pain (CBP) at different stages and identify whether these brain changes were related to the pain duration.

Patients and methods: In this study, 29 healthy individuals and 54 patients with CBP were recruited. According to the pain duration, 25 patients (3 to 12 months) were divided into the CBP-S group and 29 patients (≥ 24 months) were divided into the CBP-L group. All subjects completed clinical pain-related measurement and functional magnetic resonance imaging (fMRI) scans. Moreover, the amplitude of low-frequency fluctuation (ALFF), functional connectivity (FC), and correlation analysis were conducted in this study.

Results: Compared with healthy controls, patients in the CBP-L group showed significantly decreased ALFF in the left precuneus. In the FC analysis, patients in the CBP-S and CBP-L groups showed significantly decreased FC in several regions in the bilateral orbitofrontal cortices (OFC) and the left ventral posterior insula. Moreover, there were significant differences in the FC between the left hyper granular insula and the probabilistic area in OFC in pairwise group comparisons. The correlation analysis results demonstrated that pain duration was correlated with these functional brain changes, and the ANCOVA results revealed that pain intensity and pain interference scores did not affect the FC analysis results.

Conclusion: There are different changes in the pain neural matrix in patients with chronic pain at different stages. Furthermore, the pain duration is related to brain functional changes.

Keywords: chronic back pain; fMRI; pain duration; pain matrix; resting-state.

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Conflict of interest statement

The authors declared that there were no financial or commercial ties that might raise the possibility of a conflict of interest in the implementation of this study.

Figures

Figure 1
Figure 1
Procedures of this study.
Figure 2
Figure 2
ALFF analysis results with significant differences among groups.
Figure 3
Figure 3
Functional connectivity results with significant differences between the HC group and the two CBP groups.
Figure 4
Figure 4
The z values of functional connectivity of the HC, CBP-S, and CBP-L groups.
Figure 5
Figure 5
The functional connectivity of INS1-OFC3 of three groups.
Figure 6
Figure 6
The correlation analysis between pain duration and functional connectivity.
See this image and copyright information in PMC

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References

    1. Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082–2097. doi:10.1016/S0140-6736(21)00393-7 - DOI - PubMed
    1. Sauver JL S, Warner DO, Yawn BP, et al. Why patients visit their doctors: assessing the most prevalent conditions in a Defined American Population. Mayo Clin Proc. 2013;88(1):56–67. doi:10.1016/j.mayocp.2012.08.020 - DOI - PMC - PubMed
    1. Suzuki H, Aono S, Inoue S, et al. Clinically significant changes in pain along the Pain Intensity Numerical Rating Scale in patients with chronic low back pain. PLoS One. 2020;15(3):e0229228. doi:10.1371/journal.pone.0229228 - DOI - PMC - PubMed
    1. Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV. The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions. Neuron. 2008;60(4):570–581. doi:10.1016/j.neuron.2008.08.022 - DOI - PMC - PubMed
    1. Zhang Z, Gewandter JS, Geha P. Brain imaging biomarkers for chronic pain. Front Neurol. 2022;12. doi:10.3389/fneur.2021.734821 - DOI - PMC - PubMed