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Review
. 2024 Jul;53(7):519-526.
doi: 10.1007/s00132-024-04519-1. Epub 2024 Jun 3.

[Implant anchorage: In vivo and in vitro analyses : Clusters for implant anchorage and safety]

[Article in German]
Manuel Kistler  1 , Mareike Schonhoff  2 , Magnus Reulbach  3 , Stefan Schleifenbaum  4 , Stefanie Hölscher-Doht  5 , Christof Hurschler  3 , Alexander Jahnke  6
Affiliations
Review

[Implant anchorage: In vivo and in vitro analyses : Clusters for implant anchorage and safety]

[Article in German]
Manuel Kistler et al. Orthopadie (Heidelb). 2024 Jul.

Abstract
in English, German

Aseptic implant loosening is the primary cause of revisions in arthroplasty. Various in vitro and in vivo methods are available for assessing implant fixation and stability. The aim of the Musculoskeletal Biomechanics Research Network (MSB-NET) is to continuously improve or develop these methods. In vitro analyses are often conducted using static and dynamic ISO and ASTM standards, while RSA, DXA, and EBRA analyses are established in vivo methods for evaluating implant fixation. Primary stability analyses, as well as acoustical methods, provide additional opportunities to detect loosening early and precisely evaluate implant stability. The cluster serves as a link between basic research, clinical practice, and end users to promote in vitro and in vivo methods to improve implant safety.

Aseptische Implantatlockerung ist die Hauptursache für Revisionen in der Endoprothetik. Verschiedene In-vitro- und In-vivo-Methoden stehen zur Bewertung der Implantatverankerung und -sicherheit zur Verfügung. Ziel des Forschungsnetzwerks Muskuloskelettale Biomechanik (MSB-NET) ist es, diese Methoden kontinuierlich zu verbessern oder neu zu entwickeln. So werden In-vitro-Analysen häufig mittels statischer und dynamischer ISO- und ASTM-Standards durchgeführt, während RSA-, DXA- und EBRA-Analysen als etablierte In-vivo-Verfahren zur Bewertung der Implantatverankerung zählen. Auch Primärstabilitätsanalysen, sowie schallakustische Verfahren, bieten zusätzliche Möglichkeiten, Lockerungen frühzeitig zu erkennen und die Implantatstabilität genau zu bewerten. Das Cluster dient als Verbindung zwischen Grundlagenforschung, klinischer Praxis und Anwendern, um In-vitro- und In-vivo-Methoden zur Verbesserung der Implantatsicherheit zu fördern.

Keywords: Biomechanics; Diagnostic imaging; Medical device safety; Sonography, medical; Standardization.

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References

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