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. 2024 Oct;56(10):3381-3388.
doi: 10.1007/s11255-024-04095-5. Epub 2024 Jun 3.

The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease

Huan Zhou #  1 , Lingqiu Dong #  1 , Xiang Liu  2 , Fangming Li  1   3 , Yi Tang  1 , Wei Qin  4
Affiliations

The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease

Huan Zhou et al. Int Urol Nephrol. 2024 Oct.

Abstract

Purpose: We performed the study to investigate the association between heart rate (HR) non-dipping pattern and target organ damage in patients with chronic kidney disease (CKD) and hypertension.

Methods: In this cross-sectional study, 447 patients with CKD and hypertension were enrolled. 24 h ambulatory blood pressure monitoring was conducted. Linear regression and logistic regression analysis were conducted to investigate the association between HR non-dipping pattern and target organ damage, including estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), and left ventricular hypertrophy (LVH).

Results: Overall, 261 patients (58.4%) followed non-dipping patterns of HR. HR non-dipping pattern remained to be significantly associated with reduced eGFR (β: -0.384; 95% CI: -0.719 to -0.050; p = 0.025) and the higher prevalence of CKD stages 4-5 (OR: 2.141; 95% CI: 1.153 to 3.977; p = 0.016). Meanwhile, HR non-dipping pattern was independently associated with LVMI (β: 0.021; 95% CI: 0.000 to 0.041; p = 0.049) and LVH (OR: 1.78; 95% CI: 1.07 to 2.96; p = 0.027) after adjusting for confounding factors.

Conclusions: HR non-dipping pattern was independently associated with impaired renal function and cardiac damage. Non-dipping HR deserves further attention and needs to be detected and treated during the management of CKD patients.

Keywords: Ambulatory blood pressure monitoring; Chronic kidney disease; Heart rate non-dipping; Target organ damage.

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References

    1. GBD Chronic Kidney Disease Collaboration (2020) Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 395(10225):709–733. https://doi.org/10.1016/S0140-6736(20)30045-3 - DOI
    1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305 - DOI - PubMed
    1. Seviiri M, Lynch BM, Hodge AM, Yang Y, Liew D, English DR et al (2018) Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality. Heart 104(13):1076–1085 - DOI - PubMed
    1. Thio CHL, van Roon AM, Lefrandt JD, Gansevoort RT, Snieder H (2018) Heart rate variability and its relation to chronic kidney disease: results from the PREVEND study. Psychosom Med 80(3):307–316 - DOI - PubMed - PMC
    1. Saxena A, Minton D, Lee DC, Sui X, Fayad R, Lavie CJ et al (2013) Protective role of resting heart rate on all-cause and cardiovascular disease mortality. Mayo Clin Proc 88(12):1420–1426 - DOI - PubMed

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