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. 2024 Oct;56(10):3381-3388.
doi: 10.1007/s11255-024-04095-5. Epub 2024 Jun 3.

The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease

Huan Zhou #  1 , Lingqiu Dong #  1 , Xiang Liu  2 , Fangming Li  1   3 , Yi Tang  1 , Wei Qin  4
Affiliations

The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease

Huan Zhou et al. Int Urol Nephrol. 2024 Oct.

Abstract

Purpose: We performed the study to investigate the association between heart rate (HR) non-dipping pattern and target organ damage in patients with chronic kidney disease (CKD) and hypertension.

Methods: In this cross-sectional study, 447 patients with CKD and hypertension were enrolled. 24 h ambulatory blood pressure monitoring was conducted. Linear regression and logistic regression analysis were conducted to investigate the association between HR non-dipping pattern and target organ damage, including estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), and left ventricular hypertrophy (LVH).

Results: Overall, 261 patients (58.4%) followed non-dipping patterns of HR. HR non-dipping pattern remained to be significantly associated with reduced eGFR (β: -0.384; 95% CI: -0.719 to -0.050; p = 0.025) and the higher prevalence of CKD stages 4-5 (OR: 2.141; 95% CI: 1.153 to 3.977; p = 0.016). Meanwhile, HR non-dipping pattern was independently associated with LVMI (β: 0.021; 95% CI: 0.000 to 0.041; p = 0.049) and LVH (OR: 1.78; 95% CI: 1.07 to 2.96; p = 0.027) after adjusting for confounding factors.

Conclusions: HR non-dipping pattern was independently associated with impaired renal function and cardiac damage. Non-dipping HR deserves further attention and needs to be detected and treated during the management of CKD patients.

Keywords: Ambulatory blood pressure monitoring; Chronic kidney disease; Heart rate non-dipping; Target organ damage.

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