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. 1985 Mar;53(3):908-19.
doi: 10.1128/JVI.53.3.908-919.1985.

Measles virus P gene codes for two proteins

W J Bellini, G Englund, S Rozenblatt, H Arnheiter, C D Richardson

Measles virus P gene codes for two proteins

W J Bellini et al. J Virol. 1985 Mar.

Abstract

The entirety of the phosphoprotein gene of measles virus has been sequenced. The gene is composed of 1,657 nucleotides and specifies a 507-amino-acid protein (P). A second overlapping reading frame was predicted from the sequence and specifies a 186-amino-acid protein (C). Through the use of antisynthetic peptide antibodies, we show that both proteins are expressed in virally infected cells. Both proteins are expressed from a functionally bicistronic mRNA through independent initiation of ribosomes at the respective AUG codons. Using immunofluorescent microscopy, we localized the C protein in the nucleus and in cytoplasmic inclusions within the infected cells.

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