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Published Erratum
. 2024 Jun 11;121(24):e2408899121.
doi: 10.1073/pnas.2408899121. Epub 2024 Jun 3.

Correction for Prusiner et al., Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

No authors listed
Published Erratum

Correction for Prusiner et al., Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 3.
Fig. 3.
Inoculation of α-synuclein aggregates from MSA but not PD cases induced deposition of phosphorylated α-synuclein and reactive astrogliosis. (A) Brain homogenates were prepared from control (C1), PD, and MSA patients and IC inoculated into TgM83+/− mice. Mice inoculated with MSA homogenates, but not PD or control homogenates, showed deposition of phosphorylated α-synuclein in the brainstem (Top panels, staining with EP1536Y antibody); Insets show a 4× magnification relative to the main image. These mice also showed prominent reactive astrogliosis, as indicated by GFAP staining (Bottom). (Scale bars, 50 μm.) (B) Representative immunoblot shows total α-synuclein (Top) and detergent-insoluble phosphorylated α-synuclein (Middle) in the brains of TgM83+/− mice inoculated with homogenates from C1, PD, or MSA patients. The brain region for each inoculum is noted: FC (frontal cortex), P (pons), and SN (substantia nigra). Total α-synuclein was detected from the crude brain homogenates using the Syn211 antibody; phosphorylated α-synuclein was probed with the EP1536Y antibody. Actin is shown as a loading control (Bottom). Molecular weight markers of migrated protein standards are shown in kilodaltons. (C) Phosphorylated α-synuclein in the brains of TgM83+/− mice inoculated with PD or MSA was quantified by densitometry and expressed as an x-fold difference compared with mice inoculated with nondiseased control brain (C1). The brain-region origin for each inoculum is noted: BG (basal ganglia), FC (frontal cortex), P (pons), and SN (substantia nigra). For each inoculum, data from two animals are shown, except for the MSA11 inoculum, for which only one animal was available for biochemical analysis.
See this image and copyright information in PMC

Erratum for

  • Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
    Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Prusiner SB, et al. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17. doi: 10.1073/pnas.1514475112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324905 Free PMC article.

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