Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial

Abstract

White kidney bean (Phaseolus vulgaris L.) extracts can aid weight management by reducing calorie intake from complex carbohydrates through alpha-amylase inhibition. We examined the impact of a proprietary aqueous extract from whole dried white kidney beans standardized by its alpha-amylase inhibitor activity (Phase 2 white kidney bean extract (WKBE)) on weight management in subjects with overweight and moderate obesity. In a randomized, double-blind, placebo-controlled fashion, 81 participants completed the study and ingested either a high dose of Phase 2 (1000 mg, WKBE HIGH), a low dose (700 mg, WKBE LOW), or a matching placebo (microcrystalline cellulose, PLA) three times a day, 30 min before meals, for 12 weeks during a calorie restricted diet. In a dose-dependent manner, Phase 2 significantly reduced body weight, fat mass, BMI, waist, hip and in the WKBE HIGH group thigh circumference. Phase 2 is an effective and safe supplement aiding weight and fat loss. ClinicalTrials.gov identifier NCT02930668.

Keywords: BMI; Body shaping; Fat mass; Obesity; Weight management.

Figure 1

CONSORT Flow Diagram.

Figure 2

Changes in body weight at (A) 4 weeks (B) 8 weeks and (C) 12 weeks in response to supplementation with white kidney bean extract. *WKBE significantly different than PLA (p < 0.001). Means ± SD.

Figure 3

Changes in BMI at (A) 4 weeks (B) 8 weeks and (C) 12 weeks in response to supplementation with white kidney bean extract. *WKBE significantly different than PLA (p < 0.001). Means ± SD.

Figure 4

Changes in fat mass at (A) 4 weeks (B) 8 weeks and (C) 12 weeks and fat free mass at (D) 4 weeks (E) 8 weeks and (F) 12 weeks in response to supplementation with white kidney bean extract. *WKBE groups significantly different than PLA (p < 0.05). Means ± SD.

Figure 5

The proportion of participants who lost at least 3% of body weight at (A) 4 weeks (B) 8 weeks and (C) 12 weeks and 5% of body weight at (D) 4 weeks (E) 8 weeks and (F) 12 weeks in response to supplementation with white kidney bean extract. †WKBE HIGH significantly different than WKBE LOW. *WKBE groups significantly different than PLA (p < 0.05)..

Figure 6

Changes in waist circumference at (A) 4 weeks (B) 8 weeks and (C) 12 weeks, hip circumference at (D) 4 weeks (E) 8 weeks and (F) 12 weeks and thigh circumference at (G) 4 weeks (H) 8 weeks and (I) 12 weeks in response to supplementation of white kidney bean extract. †WKBE HIGH different than WKBE LOW. *WKBE groups significantly different than PLA (p < 0.05). Means ± SD.