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Randomized Controlled Trial
. 2024 Jul;38(7):3875-3886.
doi: 10.1007/s00464-024-10907-7. Epub 2024 Jun 3.

Laparoscopic Roux-Y-gastric bypass versus laparoscopic one-anastomosis gastric bypass for obesity: clinical & metabolic results of a prospective randomized controlled trial

Tarik Delko #  1   2   3 , Marko Kraljević #  4 , Ioannis I Lazaridis  4   5 , Thomas Köstler  4 , Anne Jomard  6   7 , Amy Taheri  6   8 , Thomas A Lutz  8 , Elena Osto  6   7   9 , Urs Zingg  4
Affiliations
Randomized Controlled Trial

Laparoscopic Roux-Y-gastric bypass versus laparoscopic one-anastomosis gastric bypass for obesity: clinical & metabolic results of a prospective randomized controlled trial

Tarik Delko et al. Surg Endosc. 2024 Jul.

Abstract

Background: One anastomosis gastric bypass (OAGB) has been proposed as an effective alternative to the current standard procedure in Switzerland, Roux-en-Y gastric bypass (RYGB). Prospective data comparing both procedures are scarce. Therefore, we performed a non-inferiority randomized controlled trial assessing the effectiveness and safety of these 2 operative techniques.

Method: Eighty patients were randomized 1:1. OAGB consisted of a very long gastric pouch with a 200 cm biliopancreatic limb, RYGB of a 150 cm ante-colic alimentary and a 60 cm biliopancreatic limb, respectively. Primary endpoint was the percent excess weight loss (%EWL) at 12 months after surgery.

Results: Mean %EWL at 12 months was 87.9% (SD24.4) in the RYGB group and 104.1% (SD24.6) in the OAGB group (p = 0.006). There was no mortality. The rate of marginal ulcers was higher in patients with OAGB compared to those with RYGB (p = 0.011), while the total number of late complications did not statistically differ between the two groups. Except for the remission of GERD, which was higher in the RYGB group compared to OAGB, there was no difference between the groups regarding the remission of comorbidities. OAGB showed improved glucose control compared to the RYGB after 1 year (p = 0.001). Furthermore, glucagon-like peptide-1 increase was significantly higher in OAGB at 6 weeks (p = 0.041) and 1 year after surgery (p = 0.029). Quality of life improved after both surgeries, without differences between the groups.

Conclusions: %EWL 1 year after surgery was higher in OAGB than in RYGB. A better glycemic control with a higher increase in GLP-1 was observed after OAGB compared to RYGB.

Trial registration: This trial is registered on ClinicalTrials.gov under the identifier NCT02601092.

Keywords: Excess weight loss; Glucagon-like peptide-1; Lipid; One anastomosis gastric bypass; Outcome; Randomized controlled trial; Roux-en-Y gastric bypass.

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References

    1. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H et al (2007) Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357(8):741–752 - DOI - PubMed
    1. Schauer PR, Bhatt DL, Kirwan JP, Wolski K, Aminian A, Brethauer SA et al (2017) Bariatric surgery versus intensive medical therapy for diabetes—5-year outcomes. N Engl J Med 376(7):641–651 - DOI - PubMed - PMC
    1. Angrisani L, Santonicola A, Iovino P, Formisano G, Buchwald H, Scopinaro N (2015) Bariatric surgery worldwide 2013. Obes Surg 25(10):1822–1832 - DOI - PubMed
    1. Rutledge R (2001) The mini-gastric bypass: experience with the first 1274 cases. Obes Surg 11(3):276–280 - DOI - PubMed
    1. De Luca M, Tie T, Ooi G, Higa K, Himpens J, Carbajo MA et al (2018) Mini gastric bypass-one anastomosis gastric bypass (MGB-OAGB)-IFSO position statement. Obes Surg 28(5):1188–1206 - DOI - PubMed

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