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Review
. 2024 Jun 3;13(1):52.
doi: 10.1186/s13741-024-00406-7.

A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery

Jerzy Kolasiński  1 , Tomasz Reysner  2 , Małgorzata Kolenda  1 , Szymon Kołacz  1 , Małgorzata Domagalska  3
Affiliations
Review

A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery

Jerzy Kolasiński et al. Perioper Med (Lond). .

Abstract

Introduction: Tranexamic acid has been widely used in plastic surgery. However, its efficacy has yet to be fully established. This meta-analysis aimed to determine its effectiveness in aesthetic plastic surgery.

Methods: Following PRISMA guidelines, we conducted a meta-analysis of prospective randomised clinical trials that compared the effects of topical or systematic administration of tranexamic acid versus the control group in aesthetic plastic surgeries. The study was registered on the International Register of Systematic Reviews (PROSPERO) and is available online ( www.crd.york.uk/prospero , CRD42023492585).

Results: Eleven studies encompassing 960 patients were included for the synthesis after critical evaluation. Systematic (MD - 18.05, 95% Cl, - 22.01, - 14.09, p < 0.00001) and topical (MD - 74.93, 95% Cl, - 88.79, - 61.07, p < 0.00001) administration of tranexamic acid reduced total blood loss. Topical tranexamic acid reduced drainage output (p < 0.0006).

Conclusion: Tranexamic acid reduced blood loss in aesthetic plastic surgery. More strictly defined RCTs, using high-quality methodology, are needed to evaluate the advantages and disadvantages of tranexamic acid in aesthetic plastic surgery.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

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Fig. 1
Risk of bias
Fig. 2
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PRISMA flow diagram
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Total blood loss, systematic tranexamic acid
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Fig. 4
Total blood loss, topical tranexamic acid
Fig. 5
Fig. 5
Drainage output, topical tranexamic acid
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Fig. 6
Haematoma, topical tranexamic acid
See this image and copyright information in PMC

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References

    1. Ausen K, Hagen AI, Østbyhaug H, Olafsson S, Kvalsund B, Spigset O, Pleym H. Topical moistening of mastectomy wounds with diluted tranexamic acid to reduce bleeding: randomized clinical trial. BJS Open. 2020;4:216–224. doi: 10.1002/bjs5.50248. - DOI - PMC - PubMed
    1. Avci H. The effect of different dose regimens of tranexamic acid in reducing blood loss in rhinoplasty: a prospective randomized controlled study. J Craniofacial Surg. 2021;32:e442–e444. doi: 10.1097/SCS.0000000000007247. - DOI - PubMed
    1. Badireddy M, Mudipalli VR. Deep venous thrombosis prophylaxis. 2018. - PubMed
    1. Beikaei M, Ghazipour A, Derakhshande V, Saki N, Nikakhlagh S. Evaluating the effect of intravenous tranexamic acid on intraoperative bleeding during elective rhinoplasty surgery. Biomed Pharmacol J. 2015;8:723–759. doi: 10.13005/bpj/779. - DOI
    1. Bloom DA, Lin CC, Manzi JE, Mojica ES, Telgheder ZL, Chapman CB, Konda SR. The efficacy of tranexamic acid for the treatment of traumatic hip fractures: a network meta-analysis. J Orthop Trauma. 2023;37:341–345. doi: 10.1097/BOT.0000000000002583. - DOI - PubMed

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