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Meta-Analysis
. 2024 Jun 3;24(1):678.
doi: 10.1186/s12885-024-12462-9.

Precancerous cervical lesion and associated factors among HIV-infected women in Ethiopia: systematic review and meta- analysis

Yeshiwas Ayale Ferede  1 , Worku Chekol Tassew  2 , Agerie Mengistie Zeleke  3
Affiliations
Meta-Analysis

Precancerous cervical lesion and associated factors among HIV-infected women in Ethiopia: systematic review and meta- analysis

Yeshiwas Ayale Ferede et al. BMC Cancer. .

Abstract

Background: Despite several preventative and control measures Ethiopia continues to see an increase in cervical cancer. Comprehensive evidence is very important to suggest ministry of health. Therefore, the aim of this study is to estimate the pooled violence of Precancerous Cervical Lesion and to identify associated factors among women living with HIV AIDS in Ethiopia.

Methods: From February 15, 2024 to March 17, 2024, systematic and methodical search of the literature was conducted using electronic databases such as PubMed, HINARI, Global Health, Scopus, EMBASE, Web of Science, African Journal online (AJOL), and Google Scholar. Quality appraisal was assessed based on Joanna Briggs Institute (JBI) critical appraisal checklist for analytical cross-sectional study using 9 criteria. The Cochrane Q and I2 test statistics were used to verify the heterogeneity of the studies. Using a fixed effect model, the pooled estimate prevalence of precancerous cervical lesion among women living with HIV was calculated.

Results: After reviewing 9,470 studies, 9 studies involving 2,910 women with HIV were included. The pooled estimate of precancerous cervical cancer among women living with HIV in Ethiopia was 15.34% (95% CI: 8.97, 21.72). Having history of sexual infection (POR = 3.12; 95% CI: 1.38, 7.05), having multiple sexual partner (POR = 3.14; 95% CI: 2.29, 4.30), and parity greater than two (POR = 4.97; 95% CI: 3.17, 7.78) were identified factors associated with precancerous cervical lesion.

Conclusion: This study found that about one-six of HIV-positive women developed precancerous cervical lesion. According to this study, there was a substantial correlation between precancerous cervical lesion among HIV-positive women and having history of sexually transmitted infection, having multiple sexual partners, and being multipara. In order to reduce precancerous cervical lesion, FMOH, policy makers, and interested parties should pay particular attention to this issue.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of study selection for systematic review and meta-analysis of precancerous cervical lesion and associated factors among HIV-positive women in Ethiopia, 2024
Fig. 2
Fig. 2
Forest plot of the pooled prevalence of precancerous cervical lesion among HIV-positive women in Ethiopia, 2024
Fig. 3
Fig. 3
Showing publication bias using funnel plot, 2024
Fig. 4
Fig. 4
Showing the forest plot of the association between sexual transmitted infection and precancerous cervical lesion in Ethiopia, 2024
Fig. 5
Fig. 5
Showing the forest plot of the association life time sexual partner and precancerous cervical lesion in Ethiopia, 2024
Fig. 6
Fig. 6
Showing the forest plot of the association between parity and precancerous cervical lesion in Ethiopia, 2024
See this image and copyright information in PMC

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