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Review
. 2024 Aug;38(8):3935-3953.
doi: 10.1002/ptr.8256. Epub 2024 Jun 3.

Genistein: A promising phytoconstituent with reference to its bioactivities

Vaishnavi Shete  1 , Nilesh M Mahajan  2 , Ruchi Shivhare  2 , Ashish Akkewar  2 , Amisha Gupta  2 , Shailendra Gurav  3
Affiliations
Review

Genistein: A promising phytoconstituent with reference to its bioactivities

Vaishnavi Shete et al. Phytother Res. 2024 Aug.

Abstract

Genistein, a potent phytoconstituent, has garnered significant attention for its diverse bioactivities, making it a subject of extensive research and exploration. This review delves into the multifaceted properties of genistein, encompassing its antioxidant and anticancer potential. Its ability to modulate various cellular pathways and interact with diverse molecular targets has positioned it as a promising candidate in the prevention and treatment of various diseases. This review provides a comprehensive examination of Genistein, covering its chemical properties, methods of isolation, synthesis, therapeutic attributes with regard to cancer management, and the proposed mechanisms of action as put forth by researchers.

Keywords: Genistein; anticancer; antioxidant; isolation; phytoconstituents; soy isoflavone.

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References

REFERENCES

    1. Aegisdottir, A. L., Tryggvason, G., Jonsdottir, A. M., & Jonasson, J. G. (2021). Salivary gland tumours in Iceland 1986‐2015: A nationwide epidemiological analysis over a 30‐year time period. APMIS, 129, 55–60.
    1. Agarwal, R. (2000). Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochemical Pharmacology, 60, 1051–1059.
    1. Akkewar, A. S., Mishra, K. M. A., Kamble, M. G., Kumar, S., Dey, J., & Sethi, K. K. (2024). A mechanistic review on growing multiple therapeutic applications of lutein and its global market research. Phytotherapy Research, 38(6), 3190–3217. https://doi.org/10.1002/ptr.8197
    1. Alvarez, J., & Emory University. (2022). Genistein supplementation to mitigate cardiometabolic dysfunction in patients undergoing androgen deprivation therapy for prostate cancer. clinicaltrials.gov. https://classic.clinicaltrials.gov/ct2/show/NCT02766478?term=genistein&a...
    1. Baker, W., Robinson, R., & Simpson, N. M. (1937). 165. Synthetical experiments in the isoflavone group. Part VIII. Note on ψ‐Baptigenin. Journal of the Chemical Society, 805–807. https://doi.org/10.1039/JR9370000805

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