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Review
. 2024 May 30:14:39-50.
doi: 10.2147/PTT.S323281. eCollection 2024.

Risk Factors for Psoriasis Flares: A Narrative Review

Luca Potestio  1 , Giuseppe Lauletta  1 , Nello Tommasino  1 , Antonio Portarapillo  1 , Antonia Salsano  1 , Teresa Battista  1 , Fabrizio Martora  1 , Matteo Megna  1
Affiliations
Review

Risk Factors for Psoriasis Flares: A Narrative Review

Luca Potestio et al. Psoriasis (Auckl). .

Abstract

Psoriasis is a chronic inflammatory cutaneous disease with multifactorial pathogenesis involving both genetic and environmental factors as well as the innate and acquired immune response. Several triggering factors may exacerbate or worsen the disease. In this context, we performed a review manuscript with the aim of investigating current literature on psoriasis risk factors, also showing possible mechanisms by which they act on psoriasis. Globally, risk factors can be divided in classic risk factors (eg, mechanical stress, infections and dysbiosis of the skin, common drugs, environment and pollution, lifestyle, psychological stress, hormonal and metabolic alterations) which have long been known to be responsible for worsening and/or reoccurrence of psoriatic manifestations, and emerging risk factors (eg, biological drugs, immunotherapy for oncologic disease, Covid-19, and vaccines) defined as those newly identified risk factors. Accurate patient information and monitoring of risk factors as well as planned follow-ups may help to prevent and treat the worsening of psoriasis and consequently improve the quality of life of psoriatic patients.

Keywords: flare; pathogenesis; psoriasis; risk factors.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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