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Case Reports
. 2024 Jun 2;12(6):e8993.
doi: 10.1002/ccr3.8993. eCollection 2024 Jun.

Mycobacterium genavense infections in immunocompromised patients with HIV: A clinical case report

Seyed Ali Dehghan Manshadi  1 , Mitra Rezaei  2 , Maryam Moradi  3 , Marjan Hemmatian  1
Affiliations
Case Reports

Mycobacterium genavense infections in immunocompromised patients with HIV: A clinical case report

Seyed Ali Dehghan Manshadi et al. Clin Case Rep. .

Abstract

Key clinical message: It is essential to consider non-tuberculosis mycobacterium in HIV-positive patients with fever, abdominal pain, weight loss, and splenomegaly.

Abstract: Mycobacterium genavense is an opportunistic slow-growing nontuberculous mycobacterium in patients with immunocompromised backgrounds, especially HIV-positive patients. In this study, we present two cases of Mycobacterium genovese infection in HIV-positive patients with a good clinical response to accurate treatment.

Keywords: HIV; Mycobacterium genavense; immunocompromised patients; nontuberculous mycobacterium.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
Chest CT scan. An 8‐mm subpleural nodule was observed in the lateral segment of the lower lobe of the right lung (RLL).
FIGURE 2
FIGURE 2
Abdomio‐pelvic CT scan. Mild splenomegaly (150 mm) and multiple mesenteric lymphadenopathies, with a conglomeration pattern and maximum size of 17 mm were detected.
FIGURE 3
FIGURE 3
Chest CT scan. There was no abnormal finding.
FIGURE 4
FIGURE 4
Abdominal CT scan. Hepatomegaly (hepatic span of 170 mm in midclavicular line) with heterogeneous enhancement and periportal edema were seen. An 8‐mm hypodense lesion with peripheral enhancement was observed in the anterior part of the sixth segment of the liver. Mild splenomegaly was seen (135 mm). Multiple mesenteric lymphadenopathies were also detected.
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References

    1. Gutierrez C, Somoskovi A. Human Pathogenic Mycobacteria. Elsevier; 2014.
    1. Baldolli A, Chocron R, Dargère S, et al. Mycobacterium genavense infections in immunocompromised patients without HIV: case series of solid organ transplant patients and literature review. Open Forum Infect Dis. 2022;9(10):ofac498. - PMC - PubMed
    1. De Wit S, Clumeck N. 94—opportunistic infections: management and prevention. In: Cohen J, Powderly WG, Opal SM, eds. Infectious Diseases. 4th ed. Elsevier; 2017:850‐858.e1.
    1. Berman SM, Kim RC, Haghighat D, Mulligan ME, Fierer J, Wyle FC. Mycobacterium genavense infection presenting as a solitary brain mass in a patient with AIDS: case report and review. Clin Infect Dis. 1994;19(6):1152‐1154. - PubMed
    1. Bourlon C, Vargas‐Serafín C, López‐Karpovitch X. Mycobacterium genavense invading the bone marrow in an HIV‐positive patient. Clin Case Reports. 2017;5(6):1043‐1045. - PMC - PubMed

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