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Comment
. 2025 Jan 17;30(1):oyae126.
doi: 10.1093/oncolo/oyae126.

Oncofusions - shaping cancer care

Giovanna Dashi  1   2 , Markku Varjosalo  1   2
Affiliations
Comment

Oncofusions - shaping cancer care

Giovanna Dashi et al. Oncologist. .

Abstract

Cancer manifests through a spectrum of mutations, including gene fusions termed oncofusions. These structural alterations influence tumorigenesis across various cancer types. Oncofusions arise primarily from genomic rearrangements and operate through deregulation or hybrid gene formation mechanisms. Notable examples such as BCR::ABL and EWS::FLI1 underscore their clinical significance. Several case studies exemplify the role of identifying and targeting oncofusions in guiding treatment decisions and improving patient outcomes. However, challenges persist in discerning drivers from passenger mutations and addressing acquired resistance. Despite advancements, the complexity of oncofusions warrants further exploration of their full potential as therapeutic targets, requiring a multidisciplinary approach integrating genomics, functional studies, and innovative drug discovery strategies to achieve precision in medicine.

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Conflict of interest statement

The authors indicated no conflicts of interest.

Figures

Figure 1.
Figure 1.
Formation and mechanisms of gene fusions.
See this image and copyright information in PMC

Comment on

References

    1. Mitelman F, Johansson B, Mertens F.. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007;7(4):233-245. 10.1038/nrc2091 - DOI - PubMed
    1. Le Guen T, Ragu S, Guirouilh-Barbat J, Lopez BS.. Role of the double-strand break repair pathway in the maintenance of genomic stability. Mol Cell Oncol. 2015;2(1):e968020. 10.4161/23723548.2014.968020 - DOI - PMC - PubMed
    1. Nowell PC, Hungerfordt DA.. Chromosome changes in human leukemia and a tentative assessment of their significance. Annals New York Academy Sci. 2006;113(2):654-662. ‌10.1111/j.1749-6632.1964.tb40697.x - DOI - PubMed
    1. Stam K, Heisterkamp N, Grosveld G, et al.. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N Engl J Med. 1985;313(23):1429-1433. 10.1056/NEJM198512053132301 - DOI - PubMed
    1. Naldini L, Stacchini A, Cirillo DM, Aglietta M, Gavosto F, Comoglio PM. Molecular and cellular biology phosphotyrosine antibodies identify the p210 c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. Mol Cell Biol. 2023;6(5):1803-1811. - PMC - PubMed