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Case Reports
. 2025 Jan 1;44(1):72-78.
doi: 10.1097/PGP.0000000000001039. Epub 2024 May 29.

POLE-mutated Endometrial "Carcinosarcoma"

Astrid De Boeck  1 , Erik Nohr  1 , Soufiane El-Hallani  2 , Prafull Ghatage  3 , Cheng Han Lee  2 , Martin Köbel  1
Affiliations
Case Reports

POLE-mutated Endometrial "Carcinosarcoma"

Astrid De Boeck et al. Int J Gynecol Pathol. .

Abstract

The molecular subtype classification of endometrial carcinomas has conceptually changed our approach to this disease. However, open questions remain about how to integrate certain histotype diagnoses with the molecular subtype. We report 2 cases with morphologic suspicion for endometrial carcinosarcoma, that still fell short of the essential criteria for diagnosing carcinosarcoma. On subsequent molecular testing pathogenic POLE mutations were detected and a descriptive diagnosis of endometrial endometrioid carcinomas, low-grade with a homologous sarcoma component was rendered. This challenges the existence of POLE-mutated "carcinosarcoma."

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Conflict of interest statement

M.K. is a consultant for HelixBiopharma, outside the scope of this study. The remaining authors declare no conflict of interest.

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References

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