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Review
. 2024 Jul 30:136:112379.
doi: 10.1016/j.intimp.2024.112379. Epub 2024 Jun 3.

Generation of CAR-TSCM: CAR-T with super clutch

Jinhui Hu  1 , Xiang Liu  2
Affiliations
Review

Generation of CAR-TSCM: CAR-T with super clutch

Jinhui Hu et al. Int Immunopharmacol. .

Abstract

CAR-T therapy has demonstrated effectiveness in hematological malignancies and is now striding into solid tumor areas. One of the main roadblocks of CAR-T therapy is T cell exhaustion normally aroused by T cell terminal differentiation due to persistent contact with antigen in vivo or in vitro manufacturing process. TSCM positions as the first, and pivotal step of naïve T cell differentiation to downstream memory and effector stages. Researchers highly seek to restrain CAR-T cells at the TSCM stage during manufacture as TSCM percentage in CAR-T products is strongly associated with better treatment response. We reviewed the recent strategies regarding CAR-TSCM generation from aspects of starting source, manufacturing process, CAR assembly, transcription factor and metabolism regulation, etc.

Keywords: CAR; CAR-T; CAR-T(SCM); T stem cell like memory; T(SCM).

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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