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. 2024 Jun 4;14(1):12769.
doi: 10.1038/s41598-024-63444-7.

Extracellular fluid excess linked to reduced choroidal vascularity index in patients with chronic kidney disease

Minjae Kang  1 , Jongrok Oh  1 , Min Kim  2 , Suk Ho Byeon  3 , Sung Soo Kim  3 , Joo Youn Shin  4
Affiliations

Extracellular fluid excess linked to reduced choroidal vascularity index in patients with chronic kidney disease

Minjae Kang et al. Sci Rep. .

Abstract

Extracellular fluid (ECF) excess is common in patients with chronic kidney disease (CKD). This study (involving 284 patients with CKD) explored the association between choroidal vascularity index (CVI) and ECF excess. We categorised patients into three groups based on extracellular water/total body water: normal, mildly overhydrated, and severely overhydrated. The more severe ECF status was associated with a lower CVI after adjustment (B = - 0.902, p = 0.001). In non-diabetic patients, both vascular luminal (LA, p < 0.001) and stromal areas (SA, p = 0.003) were significantly reduced in patients with severe ECF excess compared to others, whereas diabetic patients showed no significant differences in LA (p = 0.96) and SA (p = 0.86) based on ECF excess status. These findings suggest that ECF status may influence CVI in patients with CKD, underscoring the need for further research to clarify its direct impact on choroidal changes.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Representative images of processing to calculate the choroidal vascularity index (CVI) using enhanced depth image (EDI)– optical coherence tomography (OCT) scans. (a) original EDI-OCT image. (b) binarization of EDI-OCT image for calculation of CVI.
See this image and copyright information in PMC

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